Quantitative susceptibility mapping as an indicator of subcortical and limbic iron abnormality in Parkinson's disease with dementia

Autor: Shu-Leong Ho, Henry K.F. Mak, Queenie Chan, Grainne M. McAlonan, Nailin Yao, Shirley Yin-Yu Pang, Darrell T.H. Li, Edward S. Hui, Siew E. Chua
Rok vydání: 2018
Předmět:
Male
Parkinson's disease
Hippocampus
Gastroenterology
lcsh:RC346-429
030218 nuclear medicine & medical imaging
0302 clinical medicine
Limbic System
Medicine
10. No inequality
Brain Mapping
medicine.diagnostic_test
Brain
Regular Article
Parkinson Disease
Quantitative susceptibility mapping
Middle Aged
Amygdala
Magnetic Resonance Imaging
medicine.anatomical_structure
Neurology
lcsh:R858-859.7
Female
Disease Susceptibility
medicine.medical_specialty
Psychosis
Iron
Cognitive Neuroscience
Substantia nigra
Grey matter
lcsh:Computer applications to medicine. Medical informatics
03 medical and health sciences
Magnetic resonance imaging
Internal medicine
Humans
Dementia
Radiology
Nuclear Medicine and imaging
lcsh:Neurology. Diseases of the nervous system
Aged
business.industry
medicine.disease
Iron deposition
Neurology (clinical)
business
Biomarkers
030217 neurology & neurosurgery
Zdroj: NeuroImage: Clinical, Vol 20, Iss, Pp 365-373 (2018)
Li, D T H, Hui, E S, Chan, Q, Yao, N, Chua, S E, McAlonan, G M, Pang, S Y Y, Ho, S L & Mak, H K F 2018, ' Quantitative susceptibility mapping as an indicator of subcortical and limbic iron abnormality in Parkinson's disease with dementia ', NeuroImage: Clinical . https://doi.org/10.1016/j.nicl.2018.07.028
NeuroImage : Clinical
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2018.07.028
Popis: Late stage Parkinson's disease (PD) patients were commonly observed with other non-motor comorbidities such as dementia and psychosis. While abnormal iron level in the substantia nigra was clinically accepted as a biomarker of PD, it was also suggested that the increased iron deposition could impair other brain regions and induce non-motor symptoms. A new Magnetic Resonance Imaging (MRI) called Quantitative Susceptibility Mapping (QSM) has been found to measure iron concentration in the grey matter reliably. In this study, we investigated iron level of different subcortical and limbic structures of Parkinson's disease (PD) patients with and without dementia by QSM. QSM and volumetric analysis by MRI were performed in 10 PD dementia (PDD) patients (73 ± 6 years), 31 PD patients (63 ± 8 years) and 27 healthy controls (62 ± 7 years). No significant differences were observed in the L-Dopa equivalent dosage for the two PD groups (p = 0.125). Putative iron content was evaluated in different subcortical and limbic structures of the three groups, as well as its relationship with cognitive performance. One-way ANCOVA with FDR adjustment at level of 0.05, adjusted for age and gender, showed significant group differences for left and right hippocampus (p = 0.015 & 0.032, respectively, BH-corrected for multiple ROIs) and right thalamus (p = 0.032, BH-corrected). Post-hoc test with Bonferroni's correction suggested higher magnetic susceptibility in PDD patients than healthy controls in the left and right hippocampus (p = 0.001 & 0.047, respectively, Bonferroni's corrected), while PD patients had higher magnetic susceptibility than the healthy controls in right hippocampus and right thalamus (p = 0.006 & 0.005, respectively, Bonferroni's corrected). PDD patients also had higher susceptibility than the non-demented PD patients in left hippocampus (p = 0.046, Bonferroni's corrected). The magnetic susceptibilities of the left and right hippocampus were negatively correlated with the Mini-Mental State Examination score (r = −0.329 & -0.386, respectively; p
Highlights • This study explore association between brain iron and cognitive impairment in PD. • QSM shows iron accumulation in the hippocampus of PDD patients. • Iron in the hippocampus is correlated with cognitive function of PD patients.
Databáze: OpenAIRE
Externí odkaz: