Methotrexate-associated lymphoproliferative disorder with an osteolytic vertebral lesion in an elderly patient with rheumatoid arthritis: A case report

Autor:	Hozuka Akita, Chihiro Hirata, Tsuneaki Kenzaka
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	musculoskeletal diseases rheumatoid arthritis medicine.medical_specialty Vertebral lesion Case Report Case Reports 030226 pharmacology & pharmacy elderly methotrexate C-reactive protein Lesion 03 medical and health sciences 0302 clinical medicine immune system diseases medicine Pharmacology (medical) heterocyclic compounds 030212 general & internal medicine skin and connective tissue diseases Pharmacology biology business.industry Cancer medicine.disease Vertebra C‐reactive protein medicine.anatomical_structure Rheumatoid arthritis biology.protein Methotrexate Radiology medicine.symptom business Complication lymphoproliferative disorder medicine.drug
Zdroj:	Journal of Clinical Pharmacy and Therapeutics
ISSN:	1365-2710
Popis:	What is known and objective Methotrexate‐associated lymphoproliferative disorder (MTX‐LPD) is a rare complication that develops in patients treated with methotrexate (MTX). Case summary A 76‐year‐old male patient had been taking MTX for his rheumatoid arthritis. Computed tomography (CT) revealed masses in the liver, right adrenal gland and T6‐T7 vertebra, including an osteolytic lesion. FDG‐PET scan showed increased uptake in each lesion. MTX was discontinued, and CT showed complete remission of the tumours after three months. The disease course confirmed MTX‐LPD diagnosis. What is new and Conclusion Bone lesions in LPDs mimic those of metastatic cancer. MTX‐LPD should be considered in patients on MTX presenting with mass lesions. Bone lesions in LPDs mimic those of metastatic cancer. MTX‐LPD should be considered in patients on MTX presenting with mass lesions.
Databáze:	OpenAIRE
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