Identification of upregulated genes in oral squamous cell carcinomas
| Autor: | André Luiz Vettore, André Lopes Carvalho, Luiz Paulo Kowalski, Carlos Elias de Freitas, Felipe Rodrigues da Silva, Antonio Campos, Roberta Cardim Lessa |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Candidate gene Pathology medicine.medical_specialty Databases Factual Cell medicine.disease_cause Cohort Studies Downregulation and upregulation Predictive Value of Tests Reference Values medicine Humans Neoplasm Invasiveness RNA Neoplasm Head and neck Gene Aged Neoplasm Staging Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction Squamous Cell Carcinoma of Head and Neck business.industry Biopsy Needle Cancer Middle Aged Prognosis medicine.disease Immunohistochemistry Head and neck squamous-cell carcinoma Up-Regulation Gene Expression Regulation Neoplastic stomatognathic diseases medicine.anatomical_structure Otorhinolaryngology Head and Neck Neoplasms Carcinoma Squamous Cell Cancer research Female Mouth Neoplasms business Carcinogenesis Brazil |
| Zdroj: | Head & Neck. |
| ISSN: | 1043-3074 |
| DOI: | 10.1002/hed.23169 |
| Popis: | Background. Oral cancer is the most common subset of head and neck squamous cell carcinomas (HNSCC). These tumors often have an aggressive clinical outcome hallmarked by a propensity for local invasion and regional nodal metastasis. Upregulated genes could be useful as markers for diagnosis, prognosis, and as new drug targets for these tumors. Methods. To identify upregulated genes in oral squamous cell carcinomas (OSSCs), we examined the ORESTES public database and used a quantitative reverse transcription-polymerase chain reaction (qRT-PCR) approach to determine the expression level of selected genes in tumor samples. Results and Conclusions. The ORESTES data mining analysis indicated 40 upregulated genes in HNSCC. Nine of these candidate genes were selected for further qRT-PCR validation and 3 of them (ALDOA, AHSA1, and POLQ) were frequently found upregulated in OSCC samples, which may indicate an association of these genes with the carcinogenesis process in this tumor site and they can constitute potential new targets for therapy. V C 2012 Wiley Periodicals, Inc. Head Neck 00: 000-000, 2012 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text