Parenteral glutamine infusion alters insulin-mediated glucose metabolism
| Autor: | Phillip E. Williams, Deanna K. Levenhagen, Paul J. Flakoll, Ellen Kaizer, Myfanwy J. Borel, Kareem Jabbour |
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| Rok vydání: | 1998 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Parenteral Nutrition 030309 nutrition & dietetics medicine.medical_treatment Glutamine Medicine (miscellaneous) Carbohydrate metabolism Biology Kidney Glucagon 03 medical and health sciences 0302 clinical medicine Dogs Internal medicine medicine Glucose homeostasis Animals Homeostasis Insulin Intestinal Mucosa Infusions Intravenous Pancreatic hormone 0303 health sciences Nutrition and Dietetics Hindlimb Endocrinology Basal (medicine) Liver 030211 gastroenterology & hepatology Female Blood sampling |
| Zdroj: | JPEN. Journal of parenteral and enteral nutrition. 22(5) |
| ISSN: | 0148-6071 |
| Popis: | Glutamine is a conditionally essential amino acid that is critical for many basic cellular processes. Its supplementation has been found to be beneficial during several critical illnesses. This study examines the effects of increased glutamine availability on insulin-mediated glucose homeostasis in vivo in multicatheterized conscious canines (n = 5).Two weeks before the study, catheters were placed in the femoral artery and the portal, hepatic, femoral, and renal veins for blood sampling and in the splenic vein for intraportal infusion of insulin and glucagon. Doppler probes were placed to measure blood flow. The metabolic study consisted of equilibration, basal, and experimental periods during which [3-3H]glucose was infused to measure glucose kinetics. During the 5-hour experimental period, a hyperinsulinemic-euglycemic clamp was performed by infusing somatostatin, basal glucagon, fivefold basal insulin, and glucose to maintain euglycemia. The experimental period was divided evenly into two subperiods performed in random order: (1) i.v. glutamine infusion (0.72 mmol kg(-1) h(-1)) and (2) i.v. saline infusion.With glutamine, the glucose required to maintain euglycemia was increased 46% over saline (6.8 +/- 1.0 to 9.9 +/- 1.7 mg kg(-1) min(-1). In addition, whole-body glucose production and utilization were increased by 1.4 and 4.6 mg kg(-1) min(-1), respectively. Finally, the increase in whole-body glucose utilization was manifested by increased hepatic and hindlimb glucose utilization.Increased glutamine availability blunted insulin's action on glucose production and enhanced insulin-mediated glucose utilization with the changes in utilization being threefold greater than the changes in production. Thus parenteral glutamine has potential benefit as a nutrient adjuvant during clinical situations associated with insulin resistance. |
| Databáze: | OpenAIRE |
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