Prognostic value of connexin43 expression in patients with clinically localized prostate cancer
| Autor: | Alma Demirović, Bozo Kruslin, Davor Tomas, Goran Benko, Goran Štimac, Borislav Spajić |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Oncology
PCA3 Prostate adenocarcinoma Biochemical recurrence Male Cancer Research medicine.medical_specialty Time Factors Urology medicine.medical_treatment Cellular differentiation Adenocarcinoma Disease-Free Survival Prostate cancer Internal medicine medicine Biomarkers Tumor Humans In patient Aged Prostatectomy business.industry Prostatic Neoplasms Middle Aged Prostate-Specific Antigen medicine.disease Prognosis connexin43 prognosis Connexin 43 Cohort Disease Progression cardiovascular system sense organs business Follow-Up Studies |
| Popis: | Connexins (Cxs) are a family of transmembrane proteins that build cell-to-cell channels in gap junctions. Gap junctions composed of Cxs have an essential role in intercellular communication, adhesion and cell differentiation. Several studies investigated the role of connexin43 (Cx43) in different carcinomas ; however, none investigated its prognostic role in prostate cancer. Cx43 expression and relationship with established prognostic features were assessed in a cohort of 102 patients treated with radical prostatectomy for clinically localized prostate adenocarcinoma. Cx43 expression in prostate cancer was significantly associated with established features indicative of worse prognosis, such as follow-up time (P < 0.001) and preoperative PSA (P < 0.007). Patients with lower Cx43 expressions in tumours have shorter follow-up time, which indicated shorter disease-free survival and higher preoperative PSA values. Furthermore, tumours with positive surgical margins (P < 0.001) showed significantly lower Cx43 expression compared with tumours without this feature. In univariate (P < 0.001) and multivariate (P = 0.014) analyses, decreased Cx43 expression was found to be a significant predictor of biochemical recurrence free-survival. Study results show the association of decreased Cx43 expression with prostate cancer progression. Moreover, Cx43 could serve as an additional prognostic marker and used together with traditional prognostic markers might help in further stratifying the risk of disease progression in patients with prostate cancer. |
| Databáze: | OpenAIRE |
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