A weight-loss Mediterranean diet/lifestyle intervention ameliorates inflammation and oxidative stress in patients with obstructive sleep apnea: results of the 'MIMOSA' randomized clinical trial
| Autor: | Eleni Perraki, Kallirroi Lamprou, Ioanna Kechribari, Michael Georgoulis, Meropi D. Kontogianni, Emmanοuil Vagiakis, Roxane Tenta, Nikos Yiannakouris, Elizabeth Fragopoulou |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Mimosa Mediterranean diet medicine.medical_treatment Medicine (miscellaneous) 030209 endocrinology & metabolism Overweight Diet Mediterranean law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Weight loss law Internal medicine medicine Humans Continuous positive airway pressure Life Style Inflammation Sleep Apnea Obstructive 030109 nutrition & dietetics Nutrition and Dietetics Intention-to-treat analysis Adiponectin business.industry medicine.disease Obstructive sleep apnea Oxidative Stress medicine.symptom business |
| Zdroj: | European Journal of Nutrition. 60:3799-3810 |
| ISSN: | 1436-6215 1436-6207 |
| DOI: | 10.1007/s00394-021-02552-w |
| Popis: | Inflammation and oxidative stress are implicated in obstructive sleep apnea (OSA) pathophysiology. We aimed at exploring whether the combination of a weight-loss Mediterranean diet/lifestyle intervention with OSA standard care, i.e., continuous positive airway pressure (CPAP) prescription, can lead to greater improvements in inflammation and oxidative stress, compared to standard care alone. This was a randomized controlled clinical trial in 187 adult, overweight patients with moderate-to-severe OSA. Participants were randomized to a standard care (SCG, n = 65), a Mediterranean diet (MDG, n = 62) or a Mediterranean lifestyle group (MLG, n = 60). All groups received OSA standard care. Intervention arms participated in a 6-month behavioral weight-loss intervention based on the Mediterranean diet, while the MLG also received counselling on physical activity and sleep habits. Seven patients were excluded and 53/180 were lost to follow-up. In intention to treat analysis (n = 180), the SCG did not exhibit changes in any of the markers assessed. Post-intervention age-, sex-, baseline- and CPAP use-adjusted plasma high sensitivity C-reactive protein levels (mg/L) were lower in the MDG and the MLG compared to the SCG (mean difference − 1.33, P = 0.039 and − 1.68, P = 0.007, respectively). The MLG also exhibited lower urinary 8-iso prostaglandin F2a levels (ng/mg creatinine) compared to the SCG and the MDG (mean difference − 1.10, P |
| Databáze: | OpenAIRE |
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