Seroprevalence of Helicobacter pylori and cagA antibodies in Iceland, Estonia and Sweden

Autor:	Bjarni Thjodleifsson, Thorarinn Gislason, Christer Janson, David Gislason, Isleifur Olafsson, Rain Jögi, Elizabet Cook, Hulda Asbjörnsdottir, Runa Bjorg Sigurjonsdottir
Rok vydání:	2007
Předmět:	Microbiology (medical) Adult Estonia Male medicine.medical_specialty Spirillaceae Iceland Antibodies Serology Body Mass Index Helicobacter Infections Bacterial Proteins Risk Factors Seroepidemiologic Studies Internal medicine Epidemiology medicine Seroprevalence CagA Humans Sweden Antigens Bacterial General Immunology and Microbiology biology Helicobacter pylori Transmission (medicine) business.industry Public health General Medicine Middle Aged bacterial infections and mycoses biology.organism_classification Body Height Infectious Diseases Cross-Sectional Studies Socioeconomic Factors Female business
Zdroj:	Scandinavian journal of infectious diseases. 39(8)
ISSN:	0036-5548
Popis:	The public health implications from H. pylori infection are considerable but the transmission routes are largely unknown. In this study, the prevalence, patient characteristics and risk factors for Helicobacter pylori infection were comparatively investigated in Iceland, Sweden and Estonia. Blood samples were collected from 1046 subjects aged approximately 25-50 y (447 in Reykjavik, 359 in Uppsala and 240 in Tartu) for determination of antibodies to H. pylori and its cagA protein. The prevalence of H. pylori antibodies was 69% in Tartu, 36% in Reykjavik and 11% in Uppsala (p0.0001). There was an increase in prevalence with age in Iceland and Sweden but not in Estonia. The prevalence of antibodies to the cagA protein in subjects seroreactive to H. pylori was lower in Reykjavik (36%) than in Uppsala (69%) and Tartu (62%) (p0.0001). H. pylori infection, as determined by seroreactivity, was positively associated with smoking and BMI. Overall, socioeconomic development during the childhood period seems to be the most important factor for the prevalence of H. pylori infection. In adults, smoking may be a contributory factor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55053120b2a809474a24b048ce366c61 https://pubmed.ncbi.nlm.nih.gov/17654344 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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