Sumatriptan Fast-Disintegrating/Rapid-Release Tablets
| Autor: | Marit D Moen, Gillian M. Keating |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Agonist medicine.drug_class Migraine Disorders Pharmacology toxicology Dosage form medicine Humans Pharmacology (medical) Randomized Controlled Trials as Topic Sumatriptan business.industry Middle Aged musculoskeletal system medicine.disease Serotonin Receptor Agonists Treatment Outcome Clinical Trials Phase III as Topic Migraine Area Under Curve Anesthesia cardiovascular system Female business Tablets Serotonin Agonist medicine.drug |
| Zdroj: | Drugs. 66:883-890 |
| ISSN: | 0012-6667 |
| DOI: | 10.2165/00003495-200666060-00018 |
| Popis: | Sumatriptan is a serotonin 5-HT(1B/1D) receptor agonist that is used for the acute treatment of migraine attacks. A new fast-disintegrating/rapid-release sumatriptan tablet (sumatriptan FDT/RRT) has been developed with the goal of speeding absorption and onset of effect compared with standard sumatriptan tablets. Bioequivalence of sumatriptan FDT/RRT tablets to standard sumatriptan tablets was established in healthy volunteers. Initial data suggest that sumatriptan FDT/RRT tablets may disintegrate faster and get emptied from the stomach faster than standard sumatriptan tablets. In a randomised, double-blind, multicentre, early intervention trial in adults with mild migraine, significantly more sumatriptan FDT/RRT 50 and 100mg recipients than placebo recipients were pain free or migraine free 2 hours after receiving study medication. Compared with placebo, pain relief was significantly greater with sumatriptan FDT/RRT 100mg at 25 and 17 minutes following administration, and with sumatriptan FDT/RRT 50mg at 50 and 30 minutes following administration, in two randomised, double-blind, multicentre trials in adults with moderate to severe migraine. Sumatriptan FDT/RRT tablets were generally well tolerated; the tolerability profile was similar to that reported for standard sumatriptan tablets in other studies. |
| Databáze: | OpenAIRE |
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