Comparison of ultrastructural changes and the anticarcinogenic effects of thymol and carvacrol on ovarian cancer cells: which is more effective?

Autor:	Gurkan Yigitturk, Feral Ozturk, Türker Çavuşoğlu, Hulya Elbe, Tuba Baygar, Melike Ozgul Onal
Přispěvatelé:	Ege Üniversitesi, MÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Elbe, Hülya, Yiğittürk, Gürkan, Baygar, Tuba, Özgül Önal, Melike, Öztürk, Feral
Rok vydání:	2020
Předmět:	0301 basic medicine Cell Survival carvacrol Apoptosis Biology Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Carvacrol antiproliferative Structural Biology Cell Line Tumor Oils Volatile medicine Anticarcinogenic Agents Humans Thymol Cell Proliferation Ovarian Neoplasms Cancer medicine.disease ultrastructure Ovarian Cancer ovarian cancer 030104 developmental biology chemistry Ultrastructure 030220 oncology & carcinogenesis Ovarian cancer cells Cancer research Plant species Cymenes Female Antiproliferative Ovarian cancer
Zdroj:	Ultrastructural Pathology. 44:193-202
ISSN:	1521-0758 0191-3123
Popis:	Ovarian cancer is the seventh most common cancer worldwide in women. Many anticancer drugs are currently used clinically have been isolated from plant species or are based on such substances. Thymol (5-methyl-2-isopropylphenol) and carvacrol are oxygenated aromatic compounds from the monoterpene group. They are the main constituents of thyme essential oil and show antiproliferative, antioxidant, and antiseptic properties. the aim of this study is to compare the antiproliferative and apoptotic effects of thymol and carvacrol on SKOV-3 ovarian cancer cell line. the cancer cells were treated with different concentrations of thymol and carvacrol (100, 200, 400, 600 mu M) at 24 h and 48 h durations. the cell viability was investigated by MTT assay and analysis of apoptosis with annexin V assay was determined. the study show that thymol and carvacrol significantly induced apoptosis in all groups as dose and time-dependent (p < .05). the data in the present study demonstrated that thymol and carvacrol have apoptotic and antiproliferative properties in a concentration-dependent manner toward ovarian cancer cells. SKOV-3 cancer cell line was much more sensitive to the toxic effect of thymol than carvacrol. Mugla Sitki Kocman University Research Projects Coordination OfficeMugla Sitki Kocman University [17/062] This study has been granted by the Mugla Sitki Kocman University Research Projects Coordination Office through Project Grant Number: (17/062). the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55013c7c3653b97a21d55a974c327840 https://doi.org/10.1080/01913123.2020.1740366 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.