Prognostic Value of Concurrent Expression of C-MYC and BCL2 in Intravascular Large B-Cell Lymphoma: A 10-Year Retrospective Study
| Autor: | Pichika Chantrathammachart, Suthinee Rutnin, Poonkiat Suchonwanit, Paisarn Boonsakan, Wimolsiri Iamsumang, Pamela Chayavichitsilp |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Article Subject Biopsy Delayed diagnosis Gastroenterology General Biochemistry Genetics and Molecular Biology Proto-Oncogene Proteins c-myc 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans In patient Aged Retrospective Studies Skin Aged 80 and over Intravascular large B-cell lymphoma General Immunology and Microbiology medicine.diagnostic_test business.industry Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease Lymphoma medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 030220 oncology & carcinogenesis Skin biopsy Medicine Immunohistochemistry Female Lymphoma Large B-Cell Diffuse Bone marrow business Research Article |
| Zdroj: | BioMed Research International, Vol 2020 (2020) BioMed Research International |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2020/1350820 |
| Popis: | Background. Intravascular large B-cell lymphoma (IVLBCL) is a variant of extranodal diffuse large B-cell lymphoma (DLBCL), characterized by the presence of a B-lymphoma cell in the lumina of small blood vessels or capillaries. Due to its extremely variable clinical manifestations, IVLBCL typically results in a delayed diagnosis and poor disease prognosis. Skin biopsy, particularly random skin biopsy, has shown a potential role in the diagnosis of IVLBCL. However, information of clinicopathological features in patients with IVLBCL diagnosed by skin biopsy is limited. Objectives. To study the clinicopathological features in relation to immunohistochemical features and to identify prognostic factors in IVLBCL patients diagnosed by skin biopsy. Materials and Methods. Clinical characteristics; laboratory, histological, and immunohistochemical findings; and therapeutic response of all biopsy-confirmed IVLBCL patients during the years 2008-2017 were retrospectively reviewed. Results. The mean age was 67.4 (±9.8) years. Fever was the most common presenting symptom, accounting for 64.7%. Cutaneous and bone marrow involvement was found in 23.5% and 35.3% of patients, respectively. Patients receiving R-CHOP showed more favorable therapeutic outcome. C-MYC/BCL2 double expressors showed significantly higher incidence rate to mortality compared with nondouble expressors (p=0.042). One-year and two-year overall survival rates were 67.2% and 53.8%, respectively. Conclusions. Skin biopsy is an effective diagnostic method for IVLBCL. Concurrent expression of C-MYC and BCL2 may be a useful prognostic indicator and should be performed in order to predict the prognosis in IVLBCL patients. |
| Databáze: | OpenAIRE |
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