Effects of ketogenic and western diets on proliferation, vasculogenesis and oxidative stress in the liver
| Autor: | Özcan Budak, Songul Doganay, Veysel Toprak, Nurten Bahtiyar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Proliferation Western Diets General Medicine Ketogenic diet medicine.disease_cause General Biochemistry Genetics and Molecular Biology Endocrinology Vasculogenesis Health Care Sciences and Services Oxidative stress Internal medicine medicine Ketogenic diet oxidative stress proliferation vasculogenesis Sağlık Bilimleri ve Hizmetleri business |
| Zdroj: | Volume: 38, Issue: 3 312-317 Journal of Experimental and Clinical Medicine Volume: 39, Issue: 1 313-313 |
| ISSN: | 1309-5129 1309-4483 |
| Popis: | In this study, it was aimed to investigate the effects of different diets on lipid peroxidation, antioxidants, proliferation and vasculogenesis in liver tissue. BALBC female rats (21) were divided as the group fed with standard chow (SC), the group fed with a ketogenic diet (KD) and the group fed with western diet (WD). The rats were fed with tap water and a rat diet specially prepared according to the determined diets for four weeks. Liver tissue oxidative damage, proliferation and vasculogenesis were evaluated using spectrophotometric and immunohistopathological methods. At the end of the experiment, it was found that the highest weight gain was in the WD group and the least weight gain was in the KD group. The mean body weight of the WD group was statistically significantly higher compared to the SC and KD groups (p0.05). These results revealed that ketogenic diet prevents tissue damage by decreasing lipid peroxidation in liver tissue as well as inducing cellular proliferation and vasculogenesis. © 2021 Ondokuz Mayis Universitesi. All rights reserved. |
| Databáze: | OpenAIRE |
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