Thromboembolic Complications in Covid-19: From Clinical Scenario to Laboratory Evidence
| Autor: | Giancarlo Agnelli, Alberto Palazzuoli, Michela Giustozzi, Edoardo Gronda, Gaetano Ruocco, Francesco Tramonte |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Science antithrombotic therapy Review 030204 cardiovascular system & hematology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine medicine In patient 030212 general & internal medicine coagulation Intensive care medicine Clinical scenario Ecology Evolution Behavior and Systematics thrombosis Disseminated intravascular coagulation business.industry Paleontology medicine.disease Thrombosis COVID-19 infection Increased risk Space and Planetary Science business Risk assessment |
| Zdroj: | Life Life, Vol 11, Iss 395, p 395 (2021) |
| ISSN: | 2075-1729 |
| Popis: | SARS-Cov-2 infection, a pandemic disease since March 2020, is associated with a high percentage of cardiovascular complications mainly of a thromboembolic (TE) nature. Although clinical patterns have been described for the assessment of patients with increased risk, many TE complications occur in patients with apparently moderate risk. Notably, a recent statement from the European Society of Cardiology (ESC) atherosclerosis and vascular biology working group pointed out the key role of vascular endothelium for the recruitment of inflammatory and thrombotic pathways responsible for both disseminated intravascular coagulation and cardiovascular complications. Therefore, a better understanding of the pathophysiological process linking infection to increased TE risk is needed in order to understand the pathways of this dangerous liaison and possibly interrupt it with appropriate treatment. In this review, we describe the histological lesions and the related blood coagulation mechanisms involved in COVID-19, we define the laboratory parameters and clinical risk factors associated with TE events, and propose a prophylactic anticoagulation treatment in relation to the risk category. Finally, we highlight the concept that a solid risk assessment based on prospective multi-center data would be the challenge for a more precise risk stratification and more appropriate treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|