Optimal flushing agents for integrated optical and acoustic imaging systems
| Autor: | Jiawen Li, Earl Steward, Dilbahar Mohar, Hataka Minami, K. Kirk Shung, Pranav M. Patel, Zhongping Chen, Qifa Zhou, Teng Ma, Claire Robertson |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Iohexol Research Papers: Imaging Biomedical Engineering Contrast Media Sensitivity and Specificity Vascular lumen Biomaterials Optical coherence tomography Intravascular ultrasound Medicine and Health Sciences medicine Animals Mannitol Ultrasonography Interventional medicine.diagnostic_test business.industry Ultrasound Reproducibility of Results Dextrans Image Enhancement Coronary Vessels Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials Flushing Rabbits sense organs Radiology medicine.symptom business Tomography Optical Coherence Optoacoustic imaging Preclinical imaging Biomedical engineering medicine.drug |
| Zdroj: | Li, Jiawen; Minami, Hataka; Steward, Earl; Ma, Teng; Mohar, Dilbahar; Robertson, Claire; et al.(2015). Optimal flushing agents for integrated optical and acoustic imaging systems. Journal of Biomedical Optics, 20(5), 056005. doi: 10.1117/1.jbo.20.5.056005. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/16t8w49k |
| ISSN: | 1083-3668 |
| DOI: | 10.1117/1.jbo.20.5.056005 |
| Popis: | An increasing number of integrated optical and acoustic intravascular imaging systems have been developed and hold great promise for accurately diagnosing vulnerable plaques and guiding atherosclerosis treatment. However, in any intravascular environment, the vascular lumen is filled with blood, a high-scattering source for optical and high-frequency ultrasound signals. Blood must be flushed away to provide clearer images. To our knowledge, no research has been performed to find the ideal flushing agent for combined optical and acoustic imaging techniques. We selected three solutions as potential flushing agents for their image-enhancing effects: mannitol, dextran, and iohexol. Testing of these flushing agents was performed in a closed-loop circulation model and in vivo on rabbits. We found that a high concentration of dextran was the most useful for simultaneous intravascular ultrasound and optical coherence tomography imaging. |
| Databáze: | OpenAIRE |
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