PET Radiotracers for CNS-Adrenergic Receptors: Developments and Perspectives
| Autor: | Nora D. Volkow, Sung Won Kim, Santosh Reddy Alluri, Kun-Eek Kil |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Central Nervous System
positron emission tomography Adrenergic receptor Central nervous system Pharmaceutical Science Review 030218 nuclear medicine & medical imaging Analytical Chemistry lcsh:QD241-441 03 medical and health sciences Norepinephrine 0302 clinical medicine lcsh:Organic chemistry Drug Discovery Animals Humans Medicine Tissue Distribution Physical and Theoretical Chemistry Receptor adrenergic receptor business.industry Organic Chemistry Human brain radiotracer Antidepressive Agents Receptors Adrenergic medicine.anatomical_structure Epinephrine Chemistry (miscellaneous) Positron-Emission Tomography Peripheral nervous system Molecular Medicine Radiopharmaceuticals business Neuroscience 030217 neurology & neurosurgery Preclinical imaging medicine.drug |
| Zdroj: | Molecules, Vol 25, Iss 4017, p 4017 (2020) Molecules |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25174017 |
| Popis: | Epinephrine (E) and norepinephrine (NE) play diverse roles in our body’s physiology. In addition to their role in the peripheral nervous system (PNS), E/NE systems including their receptors are critical to the central nervous system (CNS) and to mental health. Various antipsychotics, antidepressants, and psychostimulants exert their influence partially through different subtypes of adrenergic receptors (ARs). Despite the potential of pharmacological applications and long history of research related to E/NE systems, research efforts to identify the roles of ARs in the human brain taking advantage of imaging have been limited by the lack of subtype specific ligands for ARs and brain penetrability issues. This review provides an overview of the development of positron emission tomography (PET) radiotracers for in vivo imaging of AR system in the brain. |
| Databáze: | OpenAIRE |
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