Impact of the Chronic Omega-3 Fatty Acids Supplementation in Hemiparkinsonism Model Induced by 6-Hydroxydopamine in Rats
| Autor: | Alexandre Sales Barros, Danielle Silveira Macêdo, Gerardo Cristino Filho, Juliana Uchoa Cavalcanti, Ricardo Basto Souza, Silvânia Maria Mendes Vasconcelos, Mirna Marques Bezerra, Glauce Socorro de Barros Viana, Jonatas Cavalcante Lemos, Lissiana Magna Vasconcelos Aguiar, Thales Fontenele Moraes Pinheiro, Rafael Yuri Gouveia Crispim |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Apomorphine Substantia nigra Motor Activity Biology Toxicology Neuroprotection Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Neurochemical Internal medicine Fatty Acids Omega-3 medicine Animals Biogenic Monoamines Rats Wistar Oxidopamine Nitrites gamma-Aminobutyric Acid Pharmacology chemistry.chemical_classification Hydroxydopamine Brain Parkinson Disease General Medicine Rats Disease Models Animal 030104 developmental biology Endocrinology Monoamine neurotransmitter Biochemistry chemistry Dietary Supplements Lipid Peroxidation 030217 neurology & neurosurgery Polyunsaturated fatty acid |
| Zdroj: | Basic & Clinical Pharmacology & Toxicology. 120:523-531 |
| ISSN: | 1742-7835 |
| DOI: | 10.1111/bcpt.12713 |
| Popis: | Parkinson's disease (PD) is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra. The neuronal degeneration may result from the convergence of a number of different pathogenic factors, including apoptosis, excitotoxicity and oxidative stress. Many studies emphasize the importance of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) in vital processes such as maintenance of the properties of cell membranes and the participation in signal transduction and biodynamic activity of neuronal membranes. In this study, the protective effect of ω-3 PUFA administration on the 6-hydroxydopamine (6-OHDA) model of PD in rats was investigated. ω-3 PUFA (1.5 and 3.0 g/kg) was orally administered by gavage during 28 consecutive days to male Wistar rats. On the 4th day, hemiparkinsonism was induced through intrastriatal injection of 6-OHDA. On the 25th day, the animals were submitted to behavioural analysis. On the 28th day, after euthanasia, the brain areas were collected for neurochemical evaluation. ω-3 PUFAs (1.5 and 3.0 g/kg) restored monoamine and amino acid levels on the striatum from hemiparkinsonian rats, followed by reduction in the number of apomorphine-induced rotations and promotion of a partial locomotor recovery. In addition, ω-3 PUFAs (1.5 and 3.0 g/kg) decreased the lipid peroxidation levels and nitrite levels in the brain areas from hemiparkinsonian rats. Thus, this study suggests that supplementation with ω-3 PUFAs prevents behavioural and neurochemical disturbances induced by 6-OHDA, presenting a potential neuroprotective action. |
| Databáze: | OpenAIRE |
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