Two-Year Serial Coronary Angiographic and Intravascular Ultrasound Analysis of In-Stent Angiographic Late Lumen Loss and Ultrasonic Neointimal Volume from the TAXUS II Trial
| Autor: | Adrian P. Banning, Dariusz Dudek, Patrick W. Serruys, Gerrit Anne van Es, Nico Bruining, Zheng Zhou, Keiichi Tsuchida, Mary E. Russell, Tessa Rademaker, Joerg Koglin, Janusz Drzewiecki, Antonio Colombo, Krzysztof Zmudka, Francois Schiele |
|---|---|
| Přispěvatelé: | Erasmus MC other, Cardiology, Epidemiology |
| Rok vydání: | 2007 |
| Předmět: |
Bare-metal stent
medicine.medical_specialty Time Factors Paclitaxel medicine.medical_treatment Coronary Disease Coronary Angiography Internal medicine Intravascular ultrasound medicine Humans cardiovascular diseases Ultrasonography Interventional medicine.diagnostic_test biology Surrogate endpoint business.industry Ultrasound Graft Occlusion Vascular Stent Equipment Design equipment and supplies biology.organism_classification Tubulin Modulators Treatment Outcome surgical procedures operative Taxus Angiography Circulatory system Cardiology Stents Radiology Tunica Intima Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | American Journal of Cardiology, 99(5), 607-615. Elsevier Inc. |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/j.amjcard.2006.09.107 |
| Popis: | Late loss has been used as a reliable surrogate end point for evaluation and differentiation of short-term performance of drug-eluting stents. This study investigated the consistency between angiographic and intravascular ultrasound (IVUS) outcomes of late lumen loss (late loss) and neointimal growth to measure restenotic plaque load in TAXUS and bare metal stents. The randomized TAXUS II trial evaluates the polymer-based paclitaxel-eluting TAXUS stent in slow- and moderate-release formulations. Serial angiographic and IVUS analyses were available in 155 event-free patients (bare metal stent, 74; TAXUS stent, 81) after the procedure, at 6 months, and at 2 years. For this subanalysis, quantitative coronary angiographic (QCA) and IVUS measurements were used to derive late loss and neointimal volume. From after the procedure to 6 months, quantitative coronary angiography and IVUS showed matching results for the 2 groups with significant decreases in late loss and neointimal volume in the TAXUS versus the control group. From 6 months to 2 years, QCA and IVUS measurements also showed results similar to those in the control group, demonstrating neointimal compaction over time. However, in the TAXUS group, QCA late loss showed a nonsignificant decrease from 6 months to 2 years, whereas IVUS neointimal volume increased. In conclusion, although QCA and IVUS results were similar over the first 6 months, long-term assessment of changes in restenotic plaque load showed discrepant findings for the TAXUS. These findings suggest the need for critical reevaluation of current end points and the use of more precise techniques to detect lumen and stent boundaries. |
| Databáze: | OpenAIRE |
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