Starvation-Induced Depotentiation of Bitter Taste in Drosophila
| Autor: | Emily E. LeDue, Ellen T. Koch, Bonnie Chu, Michael D. Gordon, Roslyn Dakin, Kevin Mann |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Taste Sensory Receptor Cells Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine stomatognathic system medicine Animals Axon Long-Term Synaptic Depression 2. Zero hunger Starvation food and beverages Taste Perception Octopamine (drug) Sensory neuron 030104 developmental biology medicine.anatomical_structure Drosophila melanogaster Biochemistry chemistry Female medicine.symptom Depotentiation General Agricultural and Biological Sciences Food Deprivation Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Current biology : CB. 26(21) |
| ISSN: | 1879-0445 |
| Popis: | Nutrient deprivation can lead to dramatic changes in feeding behavior, including acceptance of foods that are normally rejected. In flies, this behavioral shift depends in part on reciprocal sensitization and desensitization of sweet and bitter taste, respectively. However, the mechanisms for bitter taste modulation remain unclear. Here, we identify a set of octopaminergic/tyraminergic neurons, named OA-VLs, that directly modulate bitter sensory neuron output in response to starvation. OA-VLs are in close proximity to bitter sensory neuron axon terminals and show reduced tonic firing following starvation. We find that octopamine and tyramine potentiate bitter sensory neuron responses, suggesting that starvation-induced reduction in OA-VL activity depotentiates bitter taste. Consistent with this model, artificial silencing of OA-VL activity induces a starvation-like reduction in bitter sensory neuron output. These results demonstrate that OA-VLs mediate a critical step in starvation-dependent bitter taste modulation, allowing flies to dynamically balance the risks associated with bitter food consumption against the threat of severe starvation. |
| Databáze: | OpenAIRE |
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