Effect of Adrenal Arterial Infusion of Different Mg2+ Concentrations on the Spontaneous Release of Catecholamines in the Anesthetized Dog
| Autor: | H. M. Brecht, Wojciech Nowaczynski, Jacques Genest, Detlev Ganten, K. Hayduk, A. Helber |
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| Rok vydání: | 1973 |
| Předmět: |
Male
medicine.medical_specialty Epinephrine Plasma renin activity General Biochemistry Genetics and Molecular Biology Norepinephrine (medication) Norepinephrine chemistry.chemical_compound Dogs Internal medicine Adrenal Glands Renin medicine Animals Anesthesia Magnesium Aldosterone Magnesium ion Adrenal gland Angiotensin II Peripheral blood Endocrinology medicine.anatomical_structure Injections Intra-Arterial chemistry Female Blood supply medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 143:39-43 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-143-37248 |
| Popis: | SummaryThe effect of magnesium ion concentration on the spontaneous release of catecholamines from the adrenal gland has been studied in anesthetized dogs under nearly physiological conditions. A very slight elevation (15-20%) of Mg2+ concentration in the blood supply of the adrenal gland was found to be sufficient to inhibit the spontaneous release of norepinephrine and epinephrine. Higher concentrations of Mg2+ (up to double the control) had still greater effects, but in this case a preferential decrease of epinephrine in the adrenal outflow resulted. A possible involvement of aldosterone in the differential release of norepinephrine and epinephrine is discussed. Plasma renin activity in peripheral blood was not affected and the effect of Mg2+ does not seem to be mediated through the renin-angiotensin system. |
| Databáze: | OpenAIRE |
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