Amelanotic malignant melanomas of the oral mucosa
| Autor: | M. Watanabe, T. Kogoh, H. Nakamura, M. Shindoh, Yutaka Yamazaki, Hiroshi Fukuda, Ken-ichi Notani, Martin M. Ferguson |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lung Neoplasms Oral cavity Diagnosis Differential Neoplasms Multiple Primary Fatal Outcome Antigens Neoplasm medicine Humans Oral mucosa Amelanotic melanoma Coloring Agents neoplasms Survival rate Lymph node Melanoma Oral Ulcer Histological examination Aged Palatal Neoplasms business.industry Pigmentation S100 Proteins Mouth Mucosa Solitary Pulmonary Nodule Melanoma Amelanotic medicine.disease Prognosis Dermatology Neoplasm Proteins Survival Rate medicine.anatomical_structure Otorhinolaryngology Lymphatic Metastasis Gingival Diseases Surgery Female Mouth Neoplasms Oral Surgery Neoplasm Recurrence Local business Melanoma-Specific Antigens Immunostaining Follow-Up Studies |
| Zdroj: | The British journal of oralmaxillofacial surgery. 40(3) |
| ISSN: | 0266-4356 |
| Popis: | Oral amelanotic melanomas are rare and the prognosis is poorer than that of pigmented melanomas because of delays in establishing the correct diagnosis and in the initiation of treatment. Amelanotic forms are also thought to be biologically more aggressive than pigmented melanomas. We have seen three cases of oral amelanotic melanomas since 1970, in two of whom the diagnosis was long delayed. Two lesions were not pigmented but one had slight pigmentation. One patient simultaneously had both an amelanotic and a pigmented melanoma in the oral cavity. Lymph node metastases and distant metastases developed in all patients, two of whom eventually died of the disease. Early diagnosis by histological examination together with immunostaining with S100 and HMB-45 are the keys to improve survival for patients with amelanotic melanoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect