The influence of race on cervical length in pregnant women in Brazil
| Autor: | Tatiana K. Hamamoto, Marcelo Santucci, Francisco Herlânio Costa Carvalho, Antonio Fernandes Moron, Rosiana Mattar, Larry J. Forney, Stephanno Gomes Pereira Sarmento, Ester Cerdeira Sabino, Iara M. Linhares, A. R. Hatanaka, Evelyn Minis, Steven S. Witkin |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Gestational Age Cervix Uteri Ultrasonography Prenatal 03 medical and health sciences 0302 clinical medicine Pregnancy RNA Ribosomal 16S medicine Humans Medical history Cervical length 030304 developmental biology Black women 0303 health sciences 030219 obstetrics & reproductive medicine Obstetrics business.industry Microbiota Pregnancy Outcome Obstetrics and Gynecology medicine.disease Race Factors Short cervix Transvaginal ultrasound Cervical Length Measurement Vagina Pediatrics Perinatology and Child Health Vaginal microbiome Premature Birth Gestation Female business Brazil Maternal Age |
| Zdroj: | Journal of Perinatal Medicine. 49:365-369 |
| ISSN: | 1619-3997 0300-5577 |
| Popis: | Objectives Short cervical length is a predictor of preterm birth. We evaluated if there were racial differences in variables associated with cervical length in pregnant Brazilian women. Methods Cervical length was determined by vaginal ultrasound in 414 women at 21 weeks gestation. All women were seen at the same clinic and analyzed by the same investigators. Women found to have a short cervix (≤25 mm) received vaginal progesterone throughout gestation. Composition of the vaginal microbiome was determined by analysis of the V1–V3 region of the gene coding for bacterial 16S ribosomal RNA. Demographic, clinical and outcome variables were determined by chart review. Subjects were 53.4% White, 37.2% mixed race and 9.4% Black. Results Pregnancy, medical history and education level were similar in all groups. Mean cervical length was shorter in Black women (28.4 mm) than in White (32.4 mm) or mixed race (32.8 mm) women (p≤0.016) as was the percentage of women with a short cervix (23.1, 12.2, 7.8% in Black, White, mixed race respectively) (p≤0.026). Mean cervical length increased with maternal age in White (p=0.001) and mixed race (p=0.045) women but not Black women. There were no differences in bacterial dominance in the vaginal microbiota between groups. Most women with a short cervix delivered at term. Conclusions We conclude that Black women in Brazil have a shorter cervical length than White or mixed race women independent of maternal age, pregnancy and demographic history or composition of the vaginal microbiome. |
| Databáze: | OpenAIRE |
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