The Use of High-Resolution Ultrasonography for Preoperative Detection of Metastases in Sentinel Lymph Nodes of Patients with Cutaneous Melanoma
| Autor: | Birger Konz, Thomas Ruzicka, Christian Kunte, Theda Schuh, Matthias Volkenandt, Monika-H. Schmid-Wendtner, Jens Baumert, Julia Eberle |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Sentinel lymph node High resolution Dermatology Sensitivity and Specificity Metastasis Predictive Value of Tests Biopsy medicine Humans Melanoma Lymph node Aged Ultrasonography medicine.diagnostic_test Sentinel Lymph Node Biopsy business.industry Cancer General Medicine Middle Aged medicine.disease Surgery medicine.anatomical_structure Lymphatic Metastasis Cutaneous melanoma Female Lymph Nodes Radiology Lymph business |
| Zdroj: | Dermatologic Surgery. 35:1757-1765 |
| ISSN: | 1076-0512 |
| Popis: | BACKGROUND Sentinel lymph node biopsy (SLNB) reliably assesses the status of the regional lymph node basins and provides prognostic information in patients with cutaneous melanoma, but is logistically demanding and expensive. OBJECTIVE The aim of this study was to evaluate the ability of high resolution B-mode ultrasonography (US) for pre-operative identification and characterization of sentinel lymph nodes (SLN) in patients with cutaneous melanoma. PATIENTS AND METHODS In a prospective trial, the use of high resolution US was assessed in 25 consecutive patients with cutaneous melanoma identified for SLNB, first, for its value in primary detection of SLN, and, second, for its value in the correct assessment of SLN after lymphoscintigraphic mapping. RESULTS High resolution B-mode US correctly identified two of 6 positive SLN. The sensitivity, specificity, positive predictive value, and negative predictive value of US were 33.3% (95% CI 43.3-77.7), 100.0% (95% CI 88.1-100.0), 100.0% (95%CI 15.8-100.0) and 87.9% (95% CI 71.8-96.6), respectively. CONCLUSION High resolution B-mode US cannot replace SLNB, especially in the detection of micrometastases, but it remains the most important method to assess the lymph node status for macrometastases presurgically. |
| Databáze: | OpenAIRE |
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