Very-Rapidly Dissolving Printlets of Isoniazid Manufactured by SLS 3D Printing: In Vitro and In Vivo Characterization

Autor:	Tahir Khuroo, Eman M. Mohamed, Sathish Dharani, Canberk Kayalar, Tanil Ozkan, Mathew A. Kuttolamadom, Ziyaur Rahman, Mansoor A. Khan
Rok vydání:	2022
Předmět:	Excipients Solubility Printing Three-Dimensional Drug Discovery Isoniazid Pharmaceutical Science Molecular Medicine X-Ray Microtomography Tablets
Zdroj:	Molecular Pharmaceutics. 19:2937-2949
ISSN:	1543-8392 1543-8384
Popis:	The focus of this research was to understand the effects of formulation and processing variables on the very-rapidly dissolving printlets of isoniazid (INH) manufactured by the selective laser sintering (SLS) three-dimensional (3D) printing method, and to characterize their physicochemical properties, stability, and pharmacokinetics. Fifteen printlet formulations were manufactured by varying the laser scanning speed (400-500 mm/s
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f0a68a6fed2d1b48c65403dc3b2b60 https://doi.org/10.1021/acs.molpharmaceut.2c00306 Zobrazit plný text záznamu