Posthypoxic amnesia: regional cerebral glucose consumption measured by positron emission tomography
| Autor: | L. E. Feinendegen, Hans Herzog, Karl-Josef Langen, Helmuth Steinmetz, T. Kuwert, S. Unverhau, Volker Hömberg |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Cerebellum Thalamus Caudate nucleus Amnesia medicine Humans Memory disorder Hypoxia Brain Brain Chemistry Intelligence Tests Temporal cortex medicine.diagnostic_test Brain Middle Aged Hypoxia (medical) medicine.disease Magnetic Resonance Imaging Glucose medicine.anatomical_structure nervous system Neurology Positron emission tomography Cerebrovascular Circulation Female Neurology (clinical) medicine.symptom Psychology Neuroscience Tomography Emission-Computed |
| Zdroj: | Journal of the Neurological Sciences. 118:10-16 |
| ISSN: | 0022-510X |
| Popis: | Using positron emission tomography (PET), the regional cerebral metabolic rate of glucose consumption (rCMRG1c) was measured in 7 subjects suffering from chronic posthypoxic amnesia and in 12 controls. In 6 of the 7 patients regional decreases in rCMRG1c below normal limits were found involving the thalamus in 3 cases, the medial temporal cortex in 2 cases, and the caudate nucleus and cerebellum in one case each. No significant decrease in rCMRG1c was observed in any of the neocortical regions in any of the patients studied. Significant differences between group means of rCMRG1c were found only for the thalamus and the medial temporal cortex. These data suggest that posthypoxic amnesia stems from damage to the medial temporal cortex and its thalamic projection areas and not from neocortical dysfunction, confirming recent theories on the genesis of amnesia in man. |
| Databáze: | OpenAIRE |
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