Internet-Assisted Cognitive Behavioral Intervention for Targeted Therapy–Related Fatigue in Chronic Myeloid Leukemia: Results From a Pilot Randomized Trial
| Autor: | Ashley M. Nelson, Javier Pinilla-Ibarz, Aasha I. Hoogland, Kendra Sweet, Hailey W. Bulls, Heather S.L. Jim, Hans Knoop, Marieke F.M. Gielissen, Kelly A. Hyland, Paul B. Jacobsen |
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| Přispěvatelé: | Medical Psychology, CCA - Cancer Treatment and Quality of Life, APH - Mental Health |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Randomization Side effect medicine.medical_treatment Pilot Projects Article Disease-Free Survival law.invention Targeted therapy 03 medical and health sciences 0302 clinical medicine Cognition Randomized controlled trial Quality of life law chronic myeloid leukemia Internal medicine Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans 030212 general & internal medicine Fatigue Aged Aged 80 and over Internet Cognitive Behavioral Therapy business.industry Cancer Middle Aged medicine.disease Cognitive behavioral therapy Treatment Outcome Oncology 030220 oncology & carcinogenesis randomized controlled trial Quality of Life Female business |
| Zdroj: | Cancer Cancer, 126(1), 174-180. John Wiley and Sons Inc. |
| ISSN: | 0008-543X |
| Popis: | BACKGROUND: Fatigue is a common and disabling side effect of targeted therapies such as tyrosine kinase inhibitors (TKIs) used to treat chronic myeloid leukemia (CML). The goal of the current study was to conduct a pilot randomized trial of the first cognitive behavioral intervention developed for fatigue due to targeted therapy. METHODS: Patients with CML treated with a TKI who were reporting moderate to severe fatigue were recruited and randomized 2:1 to cognitive behavioral therapy for targeted therapy–related fatigue (CBT-TTF) delivered via FaceTime for the iPad or to a waitlist control (WLC) group. The outcomes were acceptability, feasibility, and preliminary efficacy for fatigue (Functional Assessment of Chronic Illness Therapy–Fatigue; primary outcome) and quality of life (Functional Assessment of Cancer Therapy–General; secondary outcome). Participants were assessed before randomization and after treatment (ie, approximately 18 weeks later). RESULTS: A total of 44 patients (mean age, 55 years; 48% female) were assigned to CBT-TTF (n = 29) or WLC (n = 15). The study participation rate was 59%. Among the patients assigned to CBT-TTF, 79% completed the intervention. Intent-to-treat analyses indicated that patients assigned to CBT-TTF demonstrated greater improvements in fatigue (d = 1.06; P < .001) and overall quality of life (d = 1.15; P = .005) than those assigned to WLC. More patients randomized to CBT-TTF than WLC demonstrated clinically significant improvements in fatigue (85% vs 29%) and quality of life (88% vs 54%; P values ≤ .016). CONCLUSIONS: CBT-TTF displays preliminary efficacy in improving fatigue and quality of life among fatigued patients with CML treated with TKIs. The findings suggest that a larger randomized study is warranted. |
| Databáze: | OpenAIRE |
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