A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58
Autor: | Cameron J. Reid, Max L. Cummins, Stefan Börjesson, Michael S. M. Brouwer, Henrik Hasman, Anette M. Hammerum, Louise Roer, Stefanie Hess, Thomas Berendonk, Kristina Nešporová, Marisa Haenni, Jean-Yves Madec, Astrid Bethe, Geovana B. Michael, Anne-Kathrin Schink, Stefan Schwarz, Monika Dolejska, Steven P. Djordjevic |
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Jazyk: | angličtina |
Rok vydání: | 2022 |
Předmět: |
Genomic Islands
Swine Virulence Factors Science General Physics and Astronomy Host Specificity Poultry General Biochemistry Genetics and Molecular Biology Bacterial evolution Evolution Molecular Species Specificity Escherichia coli Animals Humans Life Science Bacterial genomics Escherichia coli Infections Phylogeny Host Pathogen Interaction & Diagnostics Multidisciplinary Virulence Bacteriologie Bacteriology Drug Resistance Microbial 500 Naturwissenschaften und Mathematik::570 Biowissenschaften Biologie::570 Biowissenschaften Biologie Genomics General Chemistry Bacteriology Host Pathogen Interaction & Diagnostics Host Pathogen Interactie & Diagnostiek Bacteriologie Host Pathogen Interactie & Diagnostiek Molecular evolution Cattle Pathogens Genome Bacterial Plasmids |
Zdroj: | Nature Communications, 13(1) Nature Communications 13 (2022) 1 Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022) |
ISSN: | 2041-1723 |
Popis: | Escherichia coli ST58 has recently emerged as a globally disseminated uropathogen that often progresses to sepsis. Unlike most pandemic extra-intestinal pathogenic E. coli (ExPEC), which belong to pathogenic phylogroup B2, ST58 belongs to the environmental/commensal phylogroup B1. Here, we present a pan-genomic analysis of a global collection of 752 ST58 isolates from diverse sources. We identify a large ST58 sub-lineage characterized by near ubiquitous carriage of ColV plasmids, which carry genes encoding virulence factors, and by a distinct accessory genome including genes typical of the Yersiniabactin High Pathogenicity Island. This sub-lineage includes three-quarters of all ExPEC sequences in our study and has a broad host range, although poultry and porcine sources predominate. By contrast, strains isolated from cattle often lack ColV plasmids. Our data indicate that ColV plasmid acquisition contributed to the divergence of the major ST58 sub-lineage, and different sub-lineages inhabit poultry, swine and cattle. |
Databáze: | OpenAIRE |
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