Patterns of glucose use after bicuculline-induced convulsions in relationship to gamma-aminobutyric acid and mu-opioid receptors in the ventral pallidum--functional markers for the ventral pallidum
| Autor: | Lynn Churchill, Stanley R. Nelson, Peter W. Kalivas, R. Cross, Lennart Heimer, Thomas L. Pazdernik, Daniel S. Zahm |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Enkephalin Receptors Opioid mu Nucleus accumbens Substance P Bicuculline Globus Pallidus gamma-Aminobutyric acid Ventral pallidum Seizures Basal ganglia medicine Animals Molecular Biology Chemistry General Neuroscience Olfactory tubercle Rats Inbred Strains Receptors GABA-A Rats Globus pallidus Glucose nervous system Receptors Opioid Autoradiography Neurology (clinical) Neuroscience Biomarkers Developmental Biology medicine.drug |
| Zdroj: | Brain research. 581(1) |
| ISSN: | 0006-8993 |
| Popis: | Bicuculline-induced convulsions increased glucose use throughout the brain and sharply demarcated the ventral pallidum and globus pallidus. Glucose use in the nucleus accumbens also increased after bicuculline-induced convulsions, except for a circumscribed region in the dorsomedial shell. Since the projection from the nucleus accumbens to the ventral pallidum contains gamma-aminobutyric acid (GABA) and the opioid peptide, enkephalin, the pattern of increased glucose use in the ventral pallidum and nucleus accumbens after bicuculline-induced convulsions was compared to the topography of GABAA and mu-opioid receptors. The pattern of glucose use in the nucleus accumbens and ventral pallidum resembled the topography of GABAA, but differed from that of mu-opioid receptors. Bicuculline may disinhibit GABAergic efferents to the ventral pallidum resulting in a dramatic increase in glucose use within striatopallidal synaptic terminals as well as in local terminals of the pallidal projection neurons. |
| Databáze: | OpenAIRE |
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