Complete wound closure following a single topical application of a novel autologous homologous skin construct: first evaluation in an open‐label , single‐arm feasibility study in diabetic foot ulcers

Autor: Robert D. Galiano, David G. Armstrong, Paul M. Glat, Marissa J Carter, Dennis P. Orgill, William W. Li, Charles M. Zelen
Rok vydání: 2020
Předmět:
Zdroj: International Wound Journal
ISSN: 1742-481X
1742-4801
DOI: 10.1111/iwj.13404
Popis: Diabetic foot ulcers (DFUs) are a growing burden on patients and health care systems that often require multiple treatments of both conventional and advanced modalities to achieve complete wound closure. A novel autologous homologous skin construct (AHSC) has been developed to treat cutaneous defects with a single topical application, by leveraging the endogenous repair capabilities of the patient's healthy skin. The AHSC's ability to close DFUs with a single treatment was evaluated in an open‐label, single‐arm feasibility study. Eleven patients with DFUs extending up to tendon, bone, or capsule received a single topical application of AHSC. Closure was documented weekly with high‐resolution digital photography and wound planimetry. All 11 DFUs demonstrated successful graft take. Ten DFUs closed within 8 weeks. The median time‐to‐complete closure was 25 days. The mean percent area reduction for all 11 wounds at 4 weeks was 83%. There were no adverse events related to the AHSC treatment site. This pilot study demonstrated AHSC may be a viable single application topical intervention for DFUs and warrants investigation in larger, controlled studies.
Databáze: OpenAIRE
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