Outcome of Infants with Therapeutic Hypothermia after Perinatal Asphyxia and Early-Onset Sepsis
| Autor: | Katerina Steiner, Koen P. Dijkman, Inge A. Zonnenberg, Gunnar Naulaers, Aleksandra Zecic, Mariam Hakobyan, Renate Swarte, Sabrina Laroche, Hendrik J. ter Horst, Monique Rijken, Henrica L. M. van Straaten, Floris Groenendaal |
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| Přispěvatelé: | Pediatric surgery, Amsterdam Reproduction & Development (AR&D), Pediatrics |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Pediatrics Developmental Disabilities Group B 0302 clinical medicine Belgium Hypothermia Induced INFECTION Medicine and Health Sciences Therapeutic hypothermia 030212 general & internal medicine Age of Onset Netherlands Asphyxia Neonatorum Brain Diseases Gestational age Perinatology C-REACTIVE PROTEIN and Child Health Perinatal asphyxia Female SYSTEMIC HYPOTHERMIA medicine.medical_specialty Group B streptococcus Birth weight WHOLE-BODY HYPOTHERMIA Gestational Age Early-onset sepsis TERM Cerebral palsy Sepsis 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center Streptococcal Infections 030225 pediatrics medicine Humans Retrospective Studies business.industry Neonatal encephalopathy Other Research Radboud Institute for Health Sciences [Radboudumc 0] Infant Newborn NEONATAL ENCEPHALOPATHY Infant Retrospective cohort study medicine.disease Neurodevelopmental impairment Pediatrics Perinatology and Child Health Human medicine business Developmental Biology |
| Zdroj: | Neonatology, 115(2), 127-133. KARGER NEONATOLOGY Neonatology, 115(2), 127-133. S. Karger AG Neonatology, 115, 2, pp. 127-133 Neonatology, 115, 127-133 Hakobyan, M, Dijkman, K P, Laroche, S, Naulaers, G, Rijken, M, Steiner, K, van Straaten, H L M, Swarte, R M C, ter Horst, H J, Zecic, A, Zonnenberg, I A & Groenendaal, F 2019, ' Outcome of Infants with Therapeutic Hypothermia after Perinatal Asphyxia and Early-Onset Sepsis ', Neonatology, vol. 115, no. 2, pp. 127-133 . https://doi.org/10.1159/000493358 Neonatology, 115(2), 127-133. Karger Neonatology |
| ISSN: | 1661-7800 1661-7819 |
| Popis: | Background: Animal models suggest that neuroprotective effects of therapeutic hypothermia (TH) after perinatal asphyxia are reduced in infants with early-onset sepsis. Objectives: To assess the outcome of infants with perinatal asphyxia, neonatal encephalopathy, and TH in the presence of early-onset sepsis. Methods: In a retrospective cohort of 1,084 infants with perinatal asphyxia and TH, the outcome of 42 infants (gestational age 36.1–42.6 weeks and birth weight 2,280–5,240 g) with proven sepsis (n = 14) and probable sepsis (n = 28) was analyzed. Death, cerebral palsy, or a delayed development at 2 years was considered an adverse outcome. Results: Sepsis was caused mostly by group B streptococci (n = 17), other Gram-positive bacteria (n = 5), and Candida albicans (n = 1). Of the 42 infants, 9 (21.4%) died, and 5 (11.9%) showed impairments on follow-up. The outcome is comparable to the previously reported outcome of infants with TH without early-onset sepsis. Conclusion: A good outcome was reported in the majority of infants with perinatal asphyxia, TH, and early-onset sepsis. Cooling should not be withheld from these infants. |
| Databáze: | OpenAIRE |
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