Potential utility of COX-2 inhibitors in chemoprevention and chemotherapy

Autor:	Kathleen M. Leahy, Alane T. Koki, Jaime L. Masferrer
Rok vydání:	1999
Předmět:	Pharmacology biology Mechanism (biology) Angiogenesis Prostaglandin Cancer Inflammation General Medicine medicine.disease Metastasis chemistry.chemical_compound chemistry biology.protein medicine Pharmacology (medical) Arachidonic acid Cyclooxygenase medicine.symptom
Zdroj:	Expert Opinion on Investigational Drugs. 8:1623-1638
ISSN:	1744-7658 1354-3784
DOI:	10.1517/13543784.8.10.1623
Popis:	Increased prostaglandin (PG) production is associated with many inflammatory pathophysiological conditions; it is derived from arachidonic acid by either of two enzymes: cyclooxygenase-1 or -2 (COX-1 or COX-2). In addition to its role in inflammation, recent work suggests COX-2 derived prostaglandins may play a pivotal part in the maintenance of tumour viability, growth and metastasis. In this review, we summarise the non-steroidal anti-inflammatory drug (NSAID) epidemiological evidence, studies demonstrating overexpression of COX-2 in multiple human tumours and the pharmacological evidence in animal models which also support this hypothesis. We also discuss the potential functional roles of COX-2 activity during tumourigenesis, and speculate on the mechanism by which COX-2 inhibitors may exert their anticancer effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e982e218cc3089da93f519f0c926b7 https://doi.org/10.1517/13543784.8.10.1623 Zobrazit plný text záznamu