Control of obesity in Avy/a mice by 5alpha-androstan-17-one
| Autor: | D. V. Pearson, June M. Acton, T. T. Yen, J. A. Allan |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Mice Inbred A media_common.quotation_subject Dehydrogenase Biology Glucosephosphate Dehydrogenase Weight difference Cellular and Molecular Neuroscience Mice Internal medicine medicine Animals Obesity Molecular Biology Triglycerides media_common Pharmacology Appetite Cell Biology Metabolism medicine.disease 17-Ketosteroids Endocrinology Liver Toxicity Lipogenesis Molecular Medicine Female Androstanes |
| Zdroj: | Experientia. 34(12) |
| ISSN: | 0014-4754 |
| Popis: | Treating VY/WfL-Avy/a mice with 5 alpha-androston-17-one, a mammalian glucose-6-phosphate dehydrogenase inhibitor, prevented the mice from becoming obese. The weight difference between treated and control Avy/a mice was mainly due to a decreased accumulation of triacylglycerol. The compound did not suppress appetite, had no detectable toxicity and did not affect the lipogenesis rates in the liver and carcass. The weight-controlling effect of 5alpha-androstan-17-one in Avy/a mice was reversible upon withdrawal of treatment. |
| Databáze: | OpenAIRE |
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