Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes

Autor: C, Pfleger, A, Kaas, L, Hansen, B, Alizadeh, P, Hougaard, R, Holl, H, Kolb, B O, Roep, H B, Mortensen, N C, Schloot, Jan Aman, Aman
Přispěvatelé: Life Course Epidemiology (LCE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), De Beaufort, Carine [collaborator]
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Male
Chemokine
Chemokine receptor CCR5
PATHOGENESIS
CHILDHOOD
CHILDREN
Ccl4/Mip-1beta
METABOLIC-CONTROL
Ccl5/Rantes
Th2
chemistry.chemical_compound
Chemokine receptor
MELLITUS
Immunology and Allergy
PANCREATIC ACINAR-CELLS
Chemokine CCL4
Child
Chemokine CCL5
Multidisciplinary
general & others [D99] [Human health sciences]
Proinsulin
Chemokine CCL3
INSULIN-RESISTANCE
biology
C-Peptide
C-peptide
18 COUNTRIES
Ccl3/Mip-1alpha
CCL4/MIP-1beta
Child
Preschool
Disease Progression
Biological Markers
Female
Chemokines
medicine.medical_specialty
proinsulin
Multidisciplinaire
généralités & autres [D99] [Sciences de la santé humaine]
Adolescent
Receptors
CCR5
Immunology
Enzyme-Linked Immunosorbent Assay
DIAGNOSIS
disease progression
remission
children
INFLAMMATION
Internal medicine
Diabetes mellitus
medicine
Humans
Glycated Hemoglobin
Autoimmune disease
Hemoglobin A
Glycosylated
Type 1 diabetes
CCL5/RANTES
Infant
medicine.disease
Endocrinology
Diabetes Mellitus
Type 1
chemistry
inflammation
biology.protein
Biomarkers
type 1 diabetes mellitus
CCL3/MIP-1 alpha
Zdroj: Pfleger, C, Kaas, A, Hansen, L, Alizadeh, B, Hougaard, P, Holl, R, Kolb, H, Roep, B O, Mortensen, H B, Schloot, N C & Hvidøre Study Group on Childhood Diabetes 2008, ' Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes ', Clinical Immunology, vol. 128, no. 1, pp. 57-65 . https://doi.org/10.1016/j.clim.2008.03.458
Clinical Immunology, 128(1), 57-65. ACADEMIC PRESS INC ELSEVIER SCIENCE
Clinical Immunology. ACADEMIC PRESS INC ELSEVIER SCIENCE
Clinical Immunology, 128(1), 57-65. San Diego, CA: Academic Press (2008).
ISSN: 1521-6616
DOI: 10.1016/j.clim.2008.03.458
Popis: Th1 related chemokines CCL3 and CCL5 and Th2 related CCL4 as ligands of the receptor CCR5 contribute to disease development in animal models of type 1 diabetes. In humans, no data are available addressing the role of these chemokines regarding disease progression and remission. We investigated longitudinally circulating concentrations of CCR5 ligands of 256 newly diagnosed patients with type 1 diabetes. CCR5 ligands were differentially associated with beta-cell function and clinical remission. CCL5 was decreased in remitters and positively associated with HbA1c suggestive of a Th1 associated progression of the disease. Likewise, CCL3 was negatively related to C-peptide and positively associated with the beta-cell stress marker proinsulin but increased in remitters. CCL4 associated with decreased beta-cell stress shown by negative association with proinsulin. Blockage of chemokines or antagonism of CCR5 by therapeutic agents such as maraviroc may provide a new therapeutic target to ameliorate disease progression in type 1 diabetes. (C) 2008 Elsevier Inc. All rights reserved.
Databáze: OpenAIRE
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