Expression of Nrf2 and NF-κB transcription factors in breast cancer and breast fibroadenoma: Insights for a new therapeutic approach
| Autor: | Rodrigo Jose de Vasconcelos-Valença, Paulo de Tarso Moura-Borges, Aldenora Oliveira do Nascimento-Holanda, Mariella de Almeida Melo, Larysse Cardoso Campos-Verdes, Emerson Brandão Sousa, Camila Guedes Borges de Araújo, Lina Gomes dos Santos, Jackeline Lopes Viana, Benedito Borges da Silva, Pedro Vitor Lopes-Costa, André Luiz Pinho-Sobral, Fidelis Manes Neto, Renato de Oliveira Pereira, Viriato Campelo, Luiz Henrique Gebrim, Lauro Rodolpho Soares-Lopes, Ione Maria Ribeiro Soares-Lopes, Cléciton Braga Tavares, Alesse Ribeiro dos Santos, Camila Maria Simplicio-Revoredo, Eid Gonçalves Coelho, Maria da Conceição Barros-Oliveira, Maria Liduina Meneses Bezerra-Chaves |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology fibroadenoma medicine.medical_specialty NF-κB NRF2 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer Statistical significance Breast Fibroadenoma Internal medicine medicine Transcription factor business.industry Cancer Institutional review board medicine.disease Fibroadenoma 030104 developmental biology 030220 oncology & carcinogenesis immunohistochemistry Immunohistochemistry business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Background: Cancer and fibroadenoma are the most common breast tumors in women of reproductive age. Nuclear factor erythroid 2-related factor 2 (Nrf2) and the nuclear factor kappaB (NF-κB) transcription factor play an important role in the inflammatory process and in cell proliferation. However, few studies have analyzed these markers in breast cancer and fibroadenoma in women of reproductive age. Results: Light microscopy showed a higher concentration of anti-Nrf2 and anti-NF-κB-stained nuclei in breast cancer than in fibroadenoma. The mean percentage of stained nuclei for Nrf2 was 7.12 ± 5.2 and 43.21 ± 19.83 in the control and study groups, respectively (p < 0.0001). The mean percentage of anti-NF-κB was 10.75 ± 7.09 and 56.14 ± 21.19 (mean ± standard deviation) in the control and study groups, respectively (p < 0.0001). Histological grade 3 tumors showed a significantly higher expression of Nrf2 and NF-κB than grade 1 tumors (p < 0.05). Material and methods: This study was approved by the Institutional Review Board of Federal University of Piaui and all patients assigned an inform consent term prior to the study initiation. Nrf2 and NF-κB expression was evaluated by immunohistochemistry in 66 patients, divided into two groups, control (fibroadenoma, n = 36) and study (cancer, n = 30). The data were analyzed using ANOVA test and the statistical significance was established at p < 0.05. Conclusion: Nrf2 and NF-κB expression was significantly higher in breast cancer than in fibroadenoma, in addition to having a greater association with more aggressive tumors. |
| Databáze: | OpenAIRE |
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