Oxidative stress markers in neonatal respiratory distress syndrome: advanced oxidation protein products and 8-hydroxy-2-deoxyguanosine in relation to disease severity

Autor: Medhat A. El-Sayed, Ahmed S. Nada, Dina M. Shinkar, Ahmed S Farag, Saleh A Gaballah, Dina H Salama, Rania A. El-Farrash, Zeinab Anwar Elkabany, Eman L Macken, Eman Abdel Rahman Ismail
Rok vydání: 2018
Předmět:
Male
medicine.medical_specialty
Neonatal respiratory distress syndrome
Antioxidant
Time Factors
medicine.medical_treatment
Gestational Age
Protein oxidation
medicine.disease_cause
Severity of Illness Index
Lipid peroxidation
Protein Carbonylation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
030225 pediatrics
Internal medicine
Malondialdehyde
medicine
Birth Weight
Humans
Prospective Studies
Respiratory Distress Syndrome
Newborn
Clinical Research Article
business.industry
Infant
Newborn
Infant
Low Birth Weight
medicine.disease
Oxidative Stress
Endocrinology
Advanced oxidation protein products
chemistry
Advanced Oxidation Protein Products
8-Hydroxy-2'-Deoxyguanosine
Case-Control Studies
Pediatrics
Perinatology and Child Health
Breathing
Female
Lipid Peroxidation
business
030217 neurology & neurosurgery
Oxidative stress
Biomarkers
Infant
Premature
DNA Damage
Zdroj: Pediatric Research
ISSN: 1530-0447
Popis: Objective We assessed oxidant–antioxidant status and evaluated the role of lipid peroxidation, oxidative DNA damage, and protein oxidation in the development and severity of neonatal respiratory distress syndrome (RDS). Methods Forty preterm neonates with RDS were compared with another 40 preterm neonates without RDS enrolled as controls. Total antioxidant capacity (TAC), malondialdehyde (MDA), advanced oxidation protein products (AOPPs), 8-hydroxy-2-deoxyguanosine (8-OHdG), and trace elements (copper and zinc) were measured in cord blood (day 0) for all neonates and repeated on day 3 for the RDS group. Results Day 0 serum levels of MDA, AOPPs, and 8-OHdG were significantly higher in neonates with RDS than controls with a further increase on day 3. Days 0 and 3 levels of TAC, copper, and zinc were significantly lower in the RDS group compared with controls. Elevated serum levels of 8-OHdG and AOPPs were associated with severe RDS, invasive mechanical ventilation, and high mortality rate. 8-OHdG and AOPPs were positively correlated with MDA, oxygenation index, duration of ventilation, and duration of hospitalization. Conclusions Increased lipid, protein, and DNA oxidation is accompanied by alterations in the antioxidant defense status, which may play a role in the pathogenesis and severity of RDS.
Databáze: OpenAIRE
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