Inhibition of Nitric Oxide Synthase by L-NAME Promotes Cisplatin-Induced Nephrotoxicity in Male Rats
| Autor: | Fatemeh Moslemi, Zahra Pezeshki, Ardeshir Talebi, Hamid Nasri, Fatemeh Eshraghi-Jazi, Mehdi Nematbakhsh, Farzaneh Ashrafi, Maryam Moeini, Azam Mansouri |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Cisplatin
Creatinine medicine.medical_specialty Kidney Pathology biology Article Subject business.industry medicine.medical_treatment Nitric oxide Nephrotoxicity Nitric oxide synthase chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine medicine biology.protein business Saline Blood urea nitrogen medicine.drug Research Article |
| Zdroj: | ISRN Toxicology |
| DOI: | 10.1155/2013/242345 |
| Popis: | Objective. Nitric oxide (NO) has numerous important functions in the kidney. The role of NO in cisplatin (CP)-induced nephrotoxicity is not completely understood. This study was designed to determine the role of NO synthase inhibitor (L-NAME) on the severity of CP-induced nephrotoxicity in rats. Methods. Sixty four male (M) and female (F) Wistar rats were randomly divided into eight groups. The sham groups (group 1, male, n=6 and group 2, female, n=6) received saline. Groups 3 (male, n=8) and 4 (female, n=8) were treated with L-NAME (4 mg/kg, i.p.), and groups 5 (male, n=8) and 6 (female, n=8) received CP (3 mg/kg) for 7 days. Groups 7 (male, n=8) and 8 (female, n=8) were treated with L-NAME and CP for 7 days. Results. The CP-alone treated rats showed weight loss and increase in serum levels of blood urea nitrogen (BUN) and creatinine (Cr). Coadministration of L-NAME and CP did not improve weight loss, and it increased the levels of BUN and Cr in male but not in female rats (P<0.05). CP alone increased kidney damage significantly (P<0.05 ), however, the damage induced by combination of CP and L-NAME was gender-related. Conclusion. NOS inhibition by L-NAME increased CP-induced nephrotoxicity, which was gender-related. |
| Databáze: | OpenAIRE |
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