Primary cutaneous neuroendocrine carcinoma with diffuse expression of thyroid transcription factor-1: Report of two cases

Autor:	Víctor Alegre de Miquel, Daniela Subiabre-Ferrer, José María Ortiz Salvador
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Cytokeratin-20 Systemic disease Pathology medicine.medical_specialty Poor prognosis Thyroid Transcription Factor 1 Dermatology Disease 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Merkel cell carcinoma medicine lcsh:Dermatology E-IJD Case Report Thyroid Transcription Factor-1 Primary cutaneous neuroendocrine carcinoma business.industry Thyroid lcsh:RL1-803 medicine.disease medicine.anatomical_structure immunohistochemistry Immunohistochemistry primary cutaneous neuroendocrine carcinoma business
Zdroj:	Indian Journal of Dermatology, Vol 64, Iss 3, Pp 251-251 (2019) Indian Journal of Dermatology
ISSN:	1998-3611 0019-5154
Popis:	Primary cutaneous neuroendocrine carcinoma (PCNC), previously known as Merkel cell carcinoma (MCC), is a rare tumor of the skin with aggressive behavior and poor prognosis. Typically, PCNC is positive for Cytokeratin-20 (CK20) and negative for Thyroid Transcription Factor-1 (TTF-1). Rarely, CK-20 negative and TTF-1 positive PCNC have been described. We present the case of two patients with skin lesions histologically compatible with MCCs and a behavior characteristic of this disease, but with expression of TTF-1 instead of CK-20. In conclusion, there are increasing reports of TTF1+ CK20− skin lesions without signs of systemic disease which behave clinically and prognostically like a PCNC. The origin of these TTF1 tumors are, to date, unknown.
Databáze:	OpenAIRE
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