Effect of ulinastatin combined rivaroxaban on deep vein thrombosis in major orthopedic surgery
| Autor: | Ka Wang, Ying Lin Wang, Guo Yi Lv, Yi Tian, Xi Yu, Guo Gang Tian |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Deep vein medicine.medical_treatment Hematocrit chemistry.chemical_compound Rivaroxaban medicine Saline Orthopedic surgery Medicine(all) medicine.diagnostic_test business.industry General Medicine Perioperative Ulinastatin medicine.disease Thrombosis Surgery medicine.anatomical_structure chemistry Anesthesia business DVT medicine.drug |
| Zdroj: | Asian Pacific Journal of Tropical Medicine. 7(11):918-921 |
| ISSN: | 1995-7645 |
| DOI: | 10.1016/s1995-7645(14)60162-0 |
| Popis: | ObjectiveTo explore the effect of ulinastatin (UTI) continuous infusion combined Rivaroxaban on the deep vein thrombosis in patients undergoing major orthopedic surgery.MethodsForty-five patients undergoing major orthopedic surgery were randomly divided into three groups:ulinastatin continuous infusion (Uc) group, ulinastatin single injection (Us) group and control (C) group. All patients received patient-controlled intravenous analgesia (PCIA) after operation, and took Rivaroxaban 10 mg orally 12 hours after operation. Ulinastatin (5 000 U/kg) was given intravenously to both Uc and Us groups preoperatively. Group C was given isometric normal saline, group Uc was pumped UTI continuous intravenously at the end of surgery (10 000 U/kg) to 48 hours through PCIA pump. The values of hematocrit (HCT), thrombomodulin (TM), Interleukin (IL-6), thrombin-antithrombin complex (TAT), D-Dimer (D-D) were normally tested before surgery (T1), at the end of the surgery (T2), 12 hours (T3), 24 hours (T4) and 48 hours (T5) after surgery.ResultsCompared with T1, there was an upward tendency in TM, IL-6, TAT, and D-D after operation in group C group (P0.05).ConclusionsDuring the perioperative period, ulinastatin continuous infusion combined Rivaroxaban can correct blood hypercoagulability through different approaches in patients undergoing major orthopedic surgery. |
| Databáze: | OpenAIRE |
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