Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population
| Autor: | Dayane Alberton, Bruna Rodrigues Martins, Mauren Isfer Anghebem-Oliveira, Geraldo Picheth, Fabiane Gomes de Moraes Rego, Edneia A.S. Ramos |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
endocrine system diseases Endocrinology Diabetes and Metabolism genotype lcsh:Medicine Type 2 diabetes lcsh:Diseases of the endocrine glands. Clinical endocrinology 0302 clinical medicine Gene Frequency Pregnancy Risk Factors Polymorphism (computer science) Genotype Anthropometry Diabetes gestational diabetes mellitus Gestational diabetes Receptors Leptin Female Transcription Factor 7-Like 2 Protein Brazil Adult Peroxisome proliferator-activated receptor gamma medicine.medical_specialty Alpha-Ketoglutarate-Dependent Dioxygenase FTO 030209 endocrinology & metabolism Real-Time Polymerase Chain Reaction Statistics Nonparametric 03 medical and health sciences Internal medicine medicine Humans Obesity Allele frequency Genetic Association Studies Analysis of Variance Polymorphism Genetic lcsh:RC648-665 business.industry genetic variants lcsh:R Type 2 Diabetes Mellitus nutritional and metabolic diseases medicine.disease PPAR gamma Diabetes Gestational Cross-Sectional Studies 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 Case-Control Studies business polymorphisms TCF7L2 |
| Zdroj: | Archives of Endocrinology and Metabolism v.61 n.3 2017 Arquivos de Endocrinologia e Metabolismo Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM Archives of Endocrinology and Metabolism, Vol 61, Iss 3, Pp 238-248 (2017) Archives of Endocrinology and Metabolism, Volume: 61, Issue: 3, Pages: 238-248, Published: 27 MAR 2017 |
| Popis: | Objective Gestational diabetes mellitus (GDM) is a metabolic disorder that shares pathophysiologic features with type 2 diabetes mellitus. The aim of this study was to investigate the association of the polymorphisms fat mass and obesity-associated (FTO) rs1421085, leptin receptor (LEPR) rs1137100, rs1137101, peroxisome proliferator-activated receptor gamma (PPARg) rs1801282, and transcription factor 7-like 2 (TCF7L2) rs7901695 with GDM. Subjects and methods 252 unrelated Euro-Brazilian pregnant women were classified into two groups according to the 2015 criteria of the American and Brazilian Diabetes Association: healthy pregnant women (n = 125) and pregnant women with GDM (n = 127), matched by age. The polymorphisms were genotyped using fluorescent probes (TaqMan®). Results All groups were in Hardy-Weinberg equilibrium. The genotype and allele frequencies of the studied polymorphisms did not show significant differences between the groups (P > 0.05). In the healthy and GDM groups, the C allele frequencies (95% CI) of the FTO rs1421085 polymorphism were 36.8% [31–43%] and 35.0% [29–41%]; the G allele frequencies (95% CI) of the LEPR rs1137100 polymorphism were 24.8% [19–30%] and 22.8% [18–28%]; the G allele frequencies (95% CI) of the LEPR rs1137101 polymorphism were 43.6% [37–50%] and 42.9% [37–49%]; the G allele frequencies (95% CI) of the PPARg rs1801282 polymorphism were 7.6% [4–11%] and 8.3% [5–12%]; and the C allele frequencies (95% CI) of the TCF7L2 rs7901695 polymorphism were 33.6% [28–39%] and 39.0% [33–45%], respectively. Conclusion The studied polymorphisms were not associated with GDM in a Brazilian population. |
| Databáze: | OpenAIRE |
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