Effect of glucocorticoids on nasal polyposis, with detection of inflammatory response by measurement of nitric oxide levels in nasal polyp tissue
| Autor: | S Önal Gürsan, A Serpil Bilsel, T Bülbül, Ö Gümüştekin Bülbül, Oğuz Güçlü |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Treatment response Pathology Inflammatory response Administration Oral Nitric Oxide Gastroenterology Severity of Illness Index Nitric oxide chemistry.chemical_compound Nasal Polyps Internal medicine Severity of illness Medicine Humans Nasal polyps Grading (tumors) Glucocorticoids Administration Intranasal Inflammation Medical treatment business.industry General Medicine medicine.disease Nasal Mucosa Otorhinolaryngology chemistry Nasal administration Female business |
| Zdroj: | The Journal of laryngology and otology. 127(6) |
| ISSN: | 1748-5460 0022-2151 |
| Popis: | Objective:To investigate endoscopic staging, and nitric oxide levels in the polyp tissue, in patients with nasal polyposis undergoing glucocorticoid therapy.Methods:Nasal polyposis was evaluated using endoscopic staging and measurement of polyp tissue nitric oxide levels (chemiluminescence method). Forty-five nasal polyposis patients received either nasal therapy (n = 15), oral therapy (n = 15) or combined therapy (n = 15). Pre-treatment and post-treatment staging and nitric oxide levels were evaluated.Results:Endoscopic grading indicated significant post-treatment staging improvements in the oral (p = 0.016) and combined (p = 0.016) groups. Post-treatment staging differed significantly between the three groups (p = 0.041), with greater improvements in the oral and combined groups. All groups showed significantly lower post-treatment nitric oxide levels, compared with baseline, but post-treatment levels did not differ significantly between groups. A significant association was found between treatment response and nitric oxide level alteration.Conclusion:This study demonstrates the favourable effects of glucocorticoids on nasal polyposis, and alteration in nitric oxide tissue levels post-treatment. Nitric oxide level in nasal polyp tissue could be an indicator of treatment response, and may aid surgical decision-making by detecting cases that probably will not respond to medical treatment. |
| Databáze: | OpenAIRE |
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