Humanized Mice as Unique Tools for Human-Specific Studies
Autor: | Qingfeng Chen, Zhisheng Her, Kylie Su Mei Yong |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Immunology Pharmacology toxicology Population Mice SCID Review Disease pathogenesis Bioinformatics Communicable Diseases Translational Research Biomedical Mice 03 medical and health sciences 0302 clinical medicine Neoplasms Humanized mice Animals Humans Immunology and Allergy Medicine Human specific education Immunodeficient Mouse education.field_of_study Precision therapy business.industry Human diseases Drug testing General Medicine Medical research Disease Models Animal 030104 developmental biology Infectious disease (medical specialty) Humanized mouse Immunotherapy Human specificity business Genetic Background 030215 immunology |
Zdroj: | Archivum Immunologiae et Therapiae Experimentalis |
ISSN: | 1661-4917 0004-069X |
DOI: | 10.1007/s00005-018-0506-x |
Popis: | With an increasing human population, medical research is pushed to progress into an era of precision therapy. Humanized mice are at the very heart of this new forefront where it is acutely required to decipher human-specific disease pathogenesis and test an array of novel therapeutics. In this review, “humanized” mice are defined as immunodeficient mouse engrafted with functional human biological systems. Over the past decade, researchers have been conscientiously making improvements on the development of humanized mice as a model to closely recapitulate disease pathogenesis and drug mechanisms in humans. Currently, literature is rife with descriptions of novel and innovative humanized mouse models that hold a significant promise to become a panacea for drug innovations to treat and control conditions such as infectious disease and cancer. This review will focus on the background of humanized mice, diseases, and human-specific therapeutics tested on this platform as well as solutions to improve humanized mice for future clinical use. |
Databáze: | OpenAIRE |
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