Post-exposure prophylaxis (PEP) for rabies with purified chick embryo cell vaccine: a systematic literature review and meta-analysis
| Autor: | Pornthep Chanthavanich, Marije Vonk Noordegraaf, Piyali Mukherjee, Lin H. Chen, Rosa van Hoorn, Cinzia Marano, Philippe Buchy, Scott Preiss |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Injections Intradermal Rabies medicine.medical_treatment 030231 tropical medicine Immunology Disease Chick Embryo Fifteen million Injections Intramuscular Embryo cell 03 medical and health sciences 0302 clinical medicine Immunogenicity Vaccine Internal medicine Drug Discovery medicine Animals Humans 030212 general & internal medicine Post-exposure prophylaxis Pharmacology business.industry Immunogenicity Vaccination medicine.disease Antibodies Neutralizing Systematic review Rabies Vaccines Meta-analysis Molecular Medicine business Post-Exposure Prophylaxis |
| Zdroj: | Expert review of vaccines. 17(6) |
| ISSN: | 1744-8395 |
| Popis: | Introduction: Fifteen million people each year receive post-exposure prophylaxis (PEP) to prevent rabies, yet the disease remains neglected and highly under-reported. Areas covered: In this systematic literature review, we assessed the immunogenicity, efficacy, and safety of a purified chick embryo cell-culture rabies vaccine (PCECV) for PEP against rabies by intramuscular (IM) or intradermal (ID) administration. We performed meta-analyses to compare immunogenicity according to the route of vaccine administration, study population, and PEP regimen, such as number of doses, and concomitant rabies immunoglobulin. Expert commentary: There were 54 estimates of immune responses to vaccination, which showed that in the overall population, after starting PEP with PCECV by the IM or ID route (≥2.5 IU per dose), almost all individuals had rabies virus neutralizing antibody (RVNA) titers above the World Health Organization (WHO) recommended serological threshold for an adequate immune response to vaccination (RVNA ≥0.5 IU/ml by day 14). In the overall population, PCECV had an acceptable safety profile. However, given that there are 59,000 human rabies deaths reported annually, the challenge is to improve access to PCECV for PEP against human rabies. |
| Databáze: | OpenAIRE |
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