Head and neck cancer surgery during the COVID-19 pandemic: An international, multicenter, observational cohort study

Autor: Shaw, Richard, Winter, Stuart C, Glasbey, James, Ho, Michael Wing Sung, Jackson, Richard, Cicconi, Silvia, Ganly, Ian, Batstone, Martin, Rey Biel, Juan, Nankivell, Paul C, Simon, Christian, Omar, Omar, Simoes, Joana FF, Nepogodiev, Dmitri, Bhangu, Aneel, Schache, Andrew G, Siaw‐Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Glasbey, James C, Gujjuri, Rohan R, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Li, Elizabeth, Mann, Harvinder S, Marson, Ella J, McLean, Kenneth A, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Picciochi, Maria, Taylor, Elliott H, Tiwari, Abhinav, Trout, Isobel M, Venn, Mary L, Wilkin, Richard JW, Ho, Michael WS, Nankivell, Paul, Abbott, Tom EF, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeiers, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Arnaud, Alexis P, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead‐Kendall, Brittany K, Barlow, Emma, Blanco‐Colino, Ruth, Brar, Amanpreet, Minaya‐Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Desai, Anant, Saverio, Salomone Di, Drake, Thomas M, Edwards, John G, Elhadi, Muhammed, Emile, Sameh, Farik, Shebani, Fiore, Marco, Fitzgerald, J Edward, Ford, Samuel, Garmanova, Tatiana, Gallo, Gaetano, Ghosh, Dhruv, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gründl, Madalegna, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Isik, Arda, Jenkinson, Michael D, Jonker, Pascal, Kaafarani, Haytham MA, Kolias, Angelos, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Hans, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W, Aguilera Lorena, Maria, Marta Madolo, Maria, Major, Piotr, Martin, Janet, Mashbari, Hassan N, Mazingi, Dennis, Metallidis, Symeon, Mohan, Helen M, Moore, Rachel, Moszkowicz, David, Moug, Susan, Ng‐Kamstra, Joshua S, Maimbo, Mayaba, Niquen, Milagros, Ntirenganya, Faustin, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno‐Sacdalanm, Marie Dione, Pata, Francesco, Rivera, Carlos Jose Perez, Pinkney, Thomas D, van der Plas, Willemijn, Pockney, Peter, Qureshi, Ahmad, Radenkovic, Dejan, Ramos‐De la Medina, Antonio, Roberts, Keith, Roslani, April C, Rutegård, Martin, Santos, Irène, Satoi, Sohei, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A, Seyi‐Olajide, Justina O, Sharma, Neil, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Townend, Philip, Tsoulfas, Georgios, van Ramshorst, Gabrielle H, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, Wright, Naomi, Boccalatte, LA, Figari, MF, Larrañaga, JJ, Gibson, D, Moss, J, Richards, T, Vo, UG, Cope, D, Egoroff, N, Lott, N, Elliott, M, Phung, D, Batstone, M, Öfner, D, Gatti, A, Nardi, C, Oliva, R, De Cicco, R, Luksic, I, Mamic, M, Lorencin, M, Osman, N, Abdelkarem, MM, M. elghazaly, S, Nageh, MA, Saad, MM, Salah, M, Shahine, M, Bettoni, J, Dakpé, S, Devauchelle, B, Lavagen, N, Testelin, S, Boucher, S, Breheret, R, Gueutier, A, Kahn, A, Kün‐Darbois, J, Barrabe, A, Louvrier, A, Ballouhey, Q, Laloze, J, Usseglio, J, Espitalier, F, Ferron, C, Malard, O, Pergolini, I, Reim, D, Liokatis, P, Smolka, W, Nowak, K, Reinhard, T, Hölzle, F, Modabber, A, Winnand, P, Knitschke, M, Kauffmann, P, Wolfer, S, Kleeff, J, Lorenz, K, Michalski, C, Ronellenfitsch, U, Schneider, R, Betz, CS, Bewarder, J, Böttcher, A, Burg, S, Busch, CJ, Gosau, M, Koenig, D, Möckelmann, N, Smeets, R, Speth, U, Thole, S, Vollkommer, T, Zeller, N, Dafnios, N, Gkrinia, E, Hajiioannou, J, Korais, C, Koukoura, O, Saratziotis, A, Skoulakis, C, Alexoudi, V, Antoniades, K, Astreidis, I, Christidis, P, Deligiannidis, D, Grivas, T, Ioannidis, O, Kalaitsidou, I, Loutzidou, L, Mantevas, A, Michailidou, D, Paraskevopoulos, K, Politis, S, Stavroglou, A, Tatsis, D, Tilaveridis, I, Vahtsevanos, K, Venetis, G, Callanan, D, Huang, L, Ionescu, A, Sheahan, P, Barry, CP, Fitzgerald, C, Kinsella, J, Lennon, P, Timon, C, Macina, S, Bissolotti, G, Fusetti, S, Lemma, F, Bellanti, L, Bergonzani, M, Bertoli, G, D’Angelo, G, Lanfranco, D, Poli, T, Santoro, GP, Varazzani, A, Bussu, F, Perra, T, Piras, A, Porcu, A, Rizzo, D, Campisi, G, Cordova, A, Franza, M, Rinaldi, G, Toia, F, Beltramini, GA, Gianni’, A, Pignataro, L, Torretta, S, Comini, LV, Fiore, M, Giannini, L, Piazza, C, Gasparini, G, Gordini, L, Lombardi, CP, Moro, A, Saponaro, G, De Virgilio, A, Ferreli, F, Gaino, F, Mercante, G, Rossi, V, Spriano, G, Adamoli, L, Ansarin, M, Chu, F, De Berardinis, R, Mastrilli, F, Pietrobon, G, Tagliabue, M, Baietti, AM, Biasini, M, Maremonti, P, Neri, F, Prucher, GM, Ricci, S, Ruggiero, F, Zarabini, AG, Mancini, S, Marino Cosentino, L, Sagnotta, A, Cotoia, A, Lizzi, V, Vovola, F, Cipriani, R, Pignatti, M, Pinto, V, Rottoli, M, Bertelli, G, Notte, F, Balercia, P, Catarzi, L, Consorti, G, Ibrahim, A, Obeidat, K, Abou Chaar, MK, Al‐Masri, M, Al‐Najjar, H, Alawneh, F, Alsaraireh, O, Burgan, D, Salamah, AA, Liew, YT, Roslani, AC, Cordera, F, Alvarez, MR, Arrangoiz, R, Gómez‐Pedraza, A, Becerra García, FC, Alfaro‐Goldaracena, A, Buerba, GA, Mercado, MÁ, Posadas‐Trujillo, OE, Sarre, C, Souadka, A, Majbar, MA, Benkabbou, A, De Bree, R, Sholadoye, TT, Tolani, MA, Abur, PP, Ayub, B, Hassan, N, Robles, R, Fernandes, V, Ferraz, I, Teixeira, M, Breda, D, Colino, M, Correia, S, De Barros, J, De Oliveira López, AL, Garrido, S, Lázaro, A, Oliveira, JM, Rodrigues, M, Almeida, A, Cavaleiro, S, Faria, CS, Magalhães, Maia M, Santos‐Sousa, H, Silveira, H, Bandovas, JP, Borges, N, Chumbinho, B, Figueiredo de Barros, I, Frade, S, Gomes, J, Kam da Silva Andrade, A, Pereira Rodrigues, A, Pina, S, Silva, N, Silveira, Nunes I, Sousa, R, Garrido, R, Miranda, P, Rio‐Rodrigues, L, Galvão, D, Vieira, A, Faustino, A, Freitas, A, Mendes, JR, Rosa, J, Messias, J, Millan, A, Salgado, I, Santos, P, Alshahrani, M, Alsharif, F, Eskander, M, Majrashi, S, Mashat, A, Akeel, N, Farsi, A, Malibary, N, Saleem, A, Samkari, A, Trabulsi, N, Alhefdhi, A, Alomair, A, Alotaibi, N, Alresaini, F, Alsalamah, R, Alsobhi, S, Mahasin, Z, Othman, E, Velagapudi, S, Al, Habes H, Alkarak, S, Alqannas, M, Alyami, M, Alzamanan, M, Elawad, A, Abdulkareem, A, Alhassan, B, Alsaif, A, Bokhari, A, Nouh, T, Paunovic, I, Slijepcevic, N, Antic, S, Dunđerović, D, Jelovac, D, Jezdic, Z, Konstantinovic, V, Kotlar, B, Kuzmanovic, C, Lazić, M, Pajić, S, Petrovic, M, Popovic, F, Pucar, A, Romic, M, Sumrak, S, Vujanac, V, Jotic, A, Milovanovic, J, Trivic, A, Buta, M, Cvetkovic, A, Djurisic, I, Gacic, S, Goran, M, Inic, Z, Jeftic, N, Jevric, M, Jokic, V, Markovic, I, Milanović, M, Pejnovic, L, Savković, N, Spurnic, I, Stevic, D, Vucic, N, Kovacevic, B, Krdzic, I, Milutinović, V, Gális, B, Šimko, K, Espino Segura‐Illa, M, Sánchez Aniceto, G, Santas, M, Fernández, Rodríguez P, Cayetano, Paniagua L, Gómez, Fernández L, Gómez Díaz, CJ, Osorio, A, Alonso‐Lamberti, L, Carabias, A, García‐Quijada, J, Jimenez, V, Salazar, A, Valle Rubio, A, Anula, R, Cano‐Valderrama, O, Del Campo Martín, M, Díez‐Valladares, L, Domínguez, I, García, Alonso M, García, Romero E, Gómez, Latorre L, Muguerza, JM, Pizarro, MJ, Saez, Carlin P, Sánchez del Pueblo, C, Sánchez‐Pernaute, A, Sanz Ortega, G, Sanz‐Lopez, R, Torres, A, Sosa, MV, Espinosa, CA, Jimenez, Toscano M, Martorell, P, Carrasco, Prats M, Giménez, Francés C, Marco, Garrido A, Martínez Alonso, JA, Redondo Calvo, FJ, Fernández, M, Lozano, Lominchar P, Martín, L, Tousidonis, M, Alcaide, Matas F, García Pérez, JM, Troncoso, Pereira P, Mora‐Guzmán, I, Abellán, M, Achalandabaso, Boira M, Barbier, L, Caja, Vivancos P, Martin Playa, P, Di Martino, M, Muñoz de Nova, JL, Martín Pérez, E, Colao, García L, Hernandez Bartolome, MA, Serrano González, J, Chiesa‐Estomba, CM, González García, JÁ, Larruscain, E, Sistiaga‐Suárez, JA, Jariod Ferrer, UM, Simón Sanz, MV, Uson‐Bouthelier, T, Garcia‐Sancho Tellez, L, Heras, Aznar J, Maté, P, Ortega, Vázquez I, Picardo, AL, Sanchez Cabezudo Noguera, F, Serralta de Colsa, D, Pingarron‐Martin, L, Ruiz Martin, I, Enjuto, D, Martinez, Pascual P, Bescós, C, Brana, I, Caimari, B, De Pablo García‐Cuenca, A, Duran‐Valles, F, Giralt López de Sagredo, J, Pamias, J, Prat, N, Pujol, Pina R, Saez barba, M, Sund, M, Bayhan, Z, Çapoğlu, R, Firat, N, Gönüllü, E, Kocer, B, Mantoglu, B, Alintoprak, F, Çolak, E, Kucuk, GO, Uyanik, MS, Citgez, B, Tanal, M, Uludag, M, Demirli Atıcı, S, Kaya, T, Bekheit, M, Cymes, W, Elhusseini, M, Hannah, A, Ashcroft, J, Coughlin, P, Davies, RJ, Durrani, AJ, Habeeb, A, Irune, E, Luke, L, Masterson, L, Murphy, S, Singh, A, Walker, C, Waseem, S, Jones, T, 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Přispěvatelé: Pignatti, M, Rottoli, M, Cipriani, R, Pinto,V, COVIDSurg Collaborative, Department of Surgery, HUS Abdominal Center, Covid Surg Collaborative, Cordova, A, Campisi, G, Franza, M, Rinaldi, G, Toia, F, Winter, S
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Cancer Research
Infectious Disease Transmission
Settore MED/29 - CHIRURGIA MAXILLOFACCIALE
International Cooperation
Settore MED/19 - Chirurgia Plastica
coronavirus
medicine.disease_cause
Patient-to-Professional
surgery
0302 clinical medicine
80 and over
030212 general & internal medicine
Coronavirus
Aged
80 and over

Univariate analysis
COMPLICATIONS
OUTCOMES
Incidence (epidemiology)
Middle Aged
Oncology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
coronavirus disease 2019 (COVID-19)
Cohort study
Adult
medicine.medical_specialty
Infectious Disease Transmission
Patient-to-Professional

Critical Care
03 medical and health sciences
Patient safety
Young Adult
Settore MED/28 - Malattie Odontostomatologiche
medicine
Humans
Reconstructive Surgical Procedures
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Pandemics
Personal Protective Equipment
Aged
Neoplasm Staging
Surgeons
Surgical team
business.industry
Head and neck cancer
Cancer
COVID-19
Plastic Surgery Procedures
CARE
medicine.disease
3126 Surgery
anesthesiology
intensive care
radiology

Surgery
coronaviru
head and neck cancer
business
Zdroj: Cancer
ISSN: 0008-543X
Popis: Background The aims of this study were to provide data on the safety of head and neck cancer surgery currently being undertaken during the coronavirus disease 2019 (COVID-19) pandemic. Methods This international, observational cohort study comprised 1137 consecutive patients with head and neck cancer undergoing primary surgery with curative intent in 26 countries. Factors associated with severe pulmonary complications in COVID-19-positive patients and infections in the surgical team were determined by univariate analysis. Results Among the 1137 patients, the commonest sites were the oral cavity (38%) and the thyroid (21%). For oropharynx and larynx tumors, nonsurgical therapy was favored in most cases. There was evidence of surgical de-escalation of neck management and reconstruction. Overall 30-day mortality was 1.2%. Twenty-nine patients (3%) tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within 30 days of surgery; 13 of these patients (44.8%) developed severe respiratory complications, and 3.51 (10.3%) died. There were significant correlations with an advanced tumor stage and admission to critical care. Members of the surgical team tested positive within 30 days of surgery in 40 cases (3%). There were significant associations with operations in which the patients also tested positive for SARS-CoV-2 within 30 days, with a high community incidence of SARS-CoV-2, with screened patients, with oral tumor sites, and with tracheostomy. Conclusions Head and neck cancer surgery in the COVID-19 era appears safe even when surgery is prolonged and complex. The overlap in COVID-19 between patients and members of the surgical team raises the suspicion of failures in cross-infection measures or the use of personal protective equipment. Lay Summary Head and neck surgery is safe for patients during the coronavirus disease 2019 pandemic even when it is lengthy and complex. This is significant because concerns over patient safety raised in many guidelines appear not to be reflected by outcomes, even for those who have other serious illnesses or require complex reconstructions. Patients subjected to suboptimal or nonstandard treatments should be carefully followed up to optimize their cancer outcomes. The overlap between patients and surgeons testing positive for severe acute respiratory syndrome coronavirus 2 is notable and emphasizes the need for fastidious cross-infection controls and effective personal protective equipment.
Databáze: OpenAIRE