Chromosomal abnormality variation detected by G-banding is associated with prognosis of diffuse large B-cell lymphoma treated by R-CHOP-based therapy

Autor: Nobuhiko Uoshima, Shigeo Horiike, Eri Kawata, Tomoko Takimoto, Junya Kuroda, Isao Yokota, Taku Tsukamoto, Saeko Kuwahara-Ota, Yoshimi Mizuno, Saori Maegawa, Tsutomu Kobayashi, Mio Yamamoto-Sugitani, Masafumi Taniwaki, Yoshiaki Chinen, Yayoi Matsumura-Kimoto, Yuto Fujibayashi, Kazuna Tanba, Yuji Shimura, Hitoji Uchiyama
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Cancer Research
G banding
Gastroenterology
Antibodies
Monoclonal
Murine-Derived
0302 clinical medicine
International Prognostic Index
hemic and lymphatic diseases
Chromosome instability
Antineoplastic Combined Chemotherapy Protocols
Original Research
Aged
80 and over
Hazard ratio
Middle Aged
Prognosis
Treatment Outcome
Oncology
Vincristine
030220 oncology & carcinogenesis
Female
chromosomal abnormality variations
Lymphoma
Large B-Cell
Diffuse
Abnormality
Rituximab
Adult
medicine.medical_specialty
03 medical and health sciences
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
Cyclophosphamide
Chromosomal abnormality
Aged
Retrospective Studies
business.industry
diffuse large B‐cell lymphoma
Clinical Cancer Research
medicine.disease
Survival Analysis
Chromosome Banding
Lymphoma
Regimen
030104 developmental biology
Doxorubicin
Prednisone
karyotypic evolution
business
Diffuse large B-cell lymphoma
Zdroj: Cancer Medicine
ISSN: 2045-7634
Popis: Diffuse large B‐cell lymphoma (DLBCL), which is the most prevalent disease subtype of non‐Hodgkin lymphoma, is highly heterogeneous in terms of cytogenetic and molecular features. This study retrospectively investigated the clinical impact of G‐banding‐defined chromosomal abnormality on treatment outcomes of DLBCL in the era of rituximab‐containing immunochemotherapy. Of 181 patients who were diagnosed with DLBCL and treated with R‐CHOP or an R‐CHOP‐like regimen between January 2006 and April 2014, metaphase spreads were evaluable for G‐banding in 120. In these 120 patients, 40 were found to harbor a single chromosomal aberration type; 63 showed chromosomal abnormality variations (CAVs), which are defined by the presence of different types of chromosomal abnormalities in G‐banding, including 19 with two CAVs and 44 with ≥3 CAVs; and 17 had normal karyotypes. No specific chromosomal break point or numerical abnormality was associated with overall survival (OS) or progression‐free survival (PFS), but the presence of ≥3 CAVs was significantly associated with inferior OS rates (hazard ratio (HR): 2.222, 95% confidence interval (CI): 1.056–4.677, P = 0.031) and tended to be associated with shorter PFS (HR: 1.796, 95% CI: 0.965–3.344, P = 0.061). In addition, ≥3 CAVs more frequently accumulated in high‐risk patients, as defined by several conventional prognostic indices, such as the revised International Prognostic Index. In conclusion, our results suggest that the emergence of more CAVs, especially ≥3, based on chromosomal instability underlies the development of high‐risk disease features and a poor prognosis in DLBCL.
Databáze: OpenAIRE
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