Rapid in vivo assay method for type G botulinal toxin

Autor:	Cristina C. De Milan, Luis S. Mayorga, D. F. Gimenez, Olga N. Puig de Centorbi
Rok vydání:	1987
Předmět:	Botulinum Toxins Clostridium botulinum type G Dose-Response Relationship Drug Toxin Immunology Biology medicine.disease_cause Molecular biology Microbiology Mice Linear relationship In vivo Rapid assay medicine Clostridium botulinum Potency Animals Regression Analysis Biological Assay Toxin types
Zdroj:	Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology. 264(1-2)
ISSN:	0176-6724
Popis:	The survival time (ST) dose-response curve for Clostridium botulinum type G toxin was determined in mice and evaluated as a rapid assay method. As it occurs with other botulinal toxin types, the results showed a linear relationship between the logarithm of the injected dose and the logarithm of ST. The slope of the ST dose-response curve for type G toxin differed significantly from those for type A or subtype Af toxins. This parameter was altered when trypsin-activated type G toxin was used. The ST dose-response curve was rather stable. This in vivo assay method could be applied for the estimation of the potency of G toxin preparations in a short time using only some few mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54dfb7de67cb7426ce4c92b120d1cc2a https://pubmed.ncbi.nlm.nih.gov/3307234 Zobrazit plný text záznamu