Effect of darkness on inner retinal hypoxia in diabetes

Autor:	Neville Drasdo, David R. Owens, Rachel Valerie North, Zohreh Chiti
Rok vydání:	2002
Předmět:	medicine.medical_specialty Type 2 diabetes chemistry.chemical_compound Retinal Rod Photoreceptor Cells Diabetes mellitus Internal medicine Administration Inhalation medicine Humans Hypoxia Retina Diabetic Retinopathy business.industry Retinal General Medicine Diabetic retinopathy Darkness Middle Aged Hypoxia (medical) medicine.disease Oxygen medicine.anatomical_structure Endocrinology Diabetes Mellitus Type 2 chemistry Case-Control Studies medicine.symptom business Retinopathy
Zdroj:	The Lancet. 359:2251-2253
ISSN:	0140-6736
DOI:	10.1016/s0140-6736(02)09265-6
Popis:	It has been postulated that diabetic retinopathy might be initiated by hypoxia during the hours of darkness. Oscillatory potentials, which reflect inner retinal function, are reduced in diabetic patients. We tested the effect of oxygen inhalation on the amplitude of these oscillatory potentials after dark adaptation in seven patients with type 2 diabetes and eight controls. We found that the decreased oscillatory potentials induced by dark adaptation in the diabetic patients increased during oxygen inhalation to an amplitude that was not significantly different from that of the controls before oxygen. Oscillatory potentials in the controls were unaffected by oxygen. This finding strengthens support for the suggestion that diabetic patients might benefit from sleeping with night-time illumination.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54df7f6228a4cea828d22c10c56c0ded https://doi.org/10.1016/s0140-6736(02)09265-6 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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