PPARγ Pro12Ala and C161T polymorphisms, but not PPARα L162V, are associated with osteoporosis risk in Turkish postmenopausal women
| Autor: | Özlem Kurt Şirin, Hülya Yilmaz Aydoğan, Mehmet Uyar, Ayse Can |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Bone mineral
chemistry.chemical_classification medicine.medical_specialty business.industry Mesenchymal stem cell Osteoporosis Pharmaceutical Science Peroxisome proliferator-activated receptor Pharmacy medicine.disease Peroxisome proliferator-activated receptor bone mineral density osteoporosis polymorphism Bone remodeling Endocrinology chemistry Polymorphism (computer science) Health Care Sciences and Services Internal medicine Genotype medicine Sağlık Bilimleri ve Hizmetleri business Allele frequency |
| Zdroj: | Volume: 49, Issue: 1 14-19 İstanbul Journal of Pharmacy |
| ISSN: | 2587-2087 |
| Popis: | DOI : 10.26650/IstanbulJPharm.2019.18005 Stimulation of peroxisome proliferator-activated receptors (PPARs) causes mesenchymal stem cells of the human bone marrow differentiate into adipocytes instead of osteoblasts leading to a decreased number of osteoblasts and a decrease in bone mineral density (BMD). Thus, PPARs may have impacts on bone metabolism. 224 postmenopausal women (171 osteoporotic and osteopenic, 53 healthy control) were included in this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and agarose gel electrophoresis techniques were performed to detect PPARα L162V and PPARγ Pro12Ala/C161T polymorphisms. The distribution of PPARγ Pro12Ala genotype and allele frequencies was not statistically different in control and patient (osteopenic+osteoporotic) groups (p>0.05). However, in the patient group, subjects with “Pro12Pro” genotype had lower lumbar spine (L1-L4) BMD values than those with “Ala” allele (p 0.05). We suggested that PPARγ Pro12Ala and C161T gene variants might be contributing factors in the development of osteoporosis. Cite this article as : Kurt Sirin O, Yilmaz Aydogan H, Uyar M, Can A (2019). PPARγ Pro12Ala and C161T polymorphisms, but not PPARα L162V, are associated with osteoporosis risk in Turkish postmenopausal women. Istanbul J Pharm 49 (1): 14-19. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|