Anatomical pitfalls during encircling cryoablation of the left atrium for atrial fibrillation therapy in the pig

Autor: Gerard M. Guiraudon, Colette M. Guiraudon, Douglas L. Jones, Allan C. Skanes
Rok vydání: 2008
Předmět:
Zdroj: Journal of Interventional Cardiac Electrophysiology. 21:187-193
ISSN: 1572-8595
1383-875X
DOI: 10.1007/s10840-008-9205-6
Popis: We previously published encircling endocardial cryo-isolation of the pulmonary vein (PV) region. This study documented mechanisms of isolation failure using CARTO® mapping. Cryo-isolation used a modified Surgifrost® introduced via a Universal Cardiac Introducer® on the left atrial appendage. Of five pigs, two had incomplete isolation and repeat mapping: Activation was over Bachmann’s bundle (BB) in one and the coronary sinus (CS) in the other. Repeat cryoablation failed to eliminate gaps. Histologically, the BB gap had nonlesioned sub-epicardial fibres and thick fat covering the cryolesioned BB: fat protecting the epicardium from cryoablation. The inferior gap had a large CS, and a thick myocardium bridging the isthmus: myocardial thickness and CS thermal sink preventing transmural cryolesions. CARTO® mapping localized gaps. Although the CS is known to cause failure, its protective mechanism is not well documented. The BB gap is novel. These findings have important clinical implications for isolation of the PV region.
Databáze: OpenAIRE
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