Effects of the HIV treatment drugs nevirapine and efavirenz on brain creatine kinase activity
| Autor: | Celine M. Fochesato, Gislaine T. Rezin, Giselli Scaini, Pedro R. T. Romão, Jeverson Moreira, Emilio L. Streck |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Cyclopropanes
Male medicine.medical_specialty Nevirapine Efavirenz Neurology Anti-HIV Agents Central nervous system Pharmacology Hippocampus Biochemistry Energy homeostasis Mice Cellular and Molecular Neuroscience chemistry.chemical_compound immune system diseases Cerebellum Animals Medicine Enzyme Inhibitors Adverse effect Creatine Kinase Cerebral Cortex biology business.industry Brain virus diseases Reverse transcriptase Benzoxazines Neostriatum medicine.anatomical_structure chemistry Blood-Brain Barrier Alkynes biology.protein Reverse Transcriptase Inhibitors Creatine kinase Neurology (clinical) business medicine.drug |
| Zdroj: | Metabolic Brain Disease. 23:485-492 |
| ISSN: | 1573-7365 0885-7490 |
| DOI: | 10.1007/s11011-008-9109-2 |
| Popis: | Nevirapine (NVP) and efavirenz (EFV) are antiretroviral drugs belonging to potent class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) widely used for the treatment human immunodeficiency virus (HIV) infection. It has been demonstrated that NVP and EFV are able to cross the blood-brain barrier and arrive at the central nervous system (CNS), causing important adverse effects related to their presence within this tissue. Considering that the exact mechanisms responsible for CNS toxicity associated with NVP and EFV remain unknown and that creatine kinase (CK) plays an important role in cell energy homeostasis, in the present work we evaluated CK activity in brain of mice after chronic administration of these drugs. Our results demonstrated that NVP and EFV significantly inhibited CK activity in cerebellum, hippocampus, striatum and cortex of mice. Although it is difficult to extrapolate our findings to the human condition, the inhibition of brain CK activity by NVP and EFV may be associated with neurological adverse symptoms of these drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink