Interleukin-1β increases spinal cord wind-up activity in normal but not in monoarthritic rats
| Autor: | Claudio Laurido, Hernán Sáez, Teresa Pelissier, Alejandro Hernández, Mauricio Mondaca, Nandy López, Luis Constandil, Rubén Soto-Moyano, Carlos Muñoz |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Time Factors Central nervous system Arthritis Inflammation Rats Sprague-Dawley Internal medicine Reflex Monoarthritis medicine Animals Injections Spinal Dose-Response Relationship Drug business.industry General Neuroscience Chronic pain medicine.disease Spinal cord Arthritis Experimental Electric Stimulation Rats Nociception medicine.anatomical_structure Endocrinology Spinal Cord Anesthesia medicine.symptom business Interleukin-1 |
| Zdroj: | Neuroscience Letters. 342:139-142 |
| ISSN: | 0304-3940 |
| Popis: | Cytokines produced by spinal cord glia after peripheral inflammation, infection or trauma have a relevant role in the maintenance of pain states. The effect of intrathecally administered interleukin-1beta (IL-1beta) on spinal cord nociceptive transmission was studied in normal and monoarthritic rats by assessing wind-up activity in a C-fiber-mediated reflex paradigm evoked by repetitive (1 Hz) electric stimulation. Low i.t. doses of IL-1beta (0.03, 0.12, 0.5 and 2.0 ng) dose-dependently enhanced wind-up activity in normal rats, while higher doses (8.0 ng) only produced a marginal unsignificant effect. IL-1beta administration to monoarthritic rats did not significantly change wind-up scores at any dose. Adaptive changes developed in the spinal cord during chronic pain may underlie the ineffectiveness of exogenous IL-1beta to up-regulate nociceptive transmission. |
| Databáze: | OpenAIRE |
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