Synthesis of 2-(4-arylthiosemicarbazidocarbonylthio)benzthiazoles and their monoamine oxidase inhibitory and anticonvulsant properties
| Autor: | Stanley J. Brumleve, R. S. Misra, Surendra S. Parmar, S.P. Singh |
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| Rok vydání: | 1975 |
| Předmět: |
Male
Thiosemicarbazones Monoamine Oxidase Inhibitors Stereochemistry Monoamine oxidase medicine.medical_treatment Pharmaceutical Science In Vitro Techniques Inhibitory postsynaptic potential Ion Mice medicine Animals Bovine serum albumin Binding site Scatchard plot biology Chemistry Brain Binding constant Rats Thiazoles Anticonvulsant biology.protein Anticonvulsants Female |
| Zdroj: | Journal of pharmaceutical sciences. 64(7) |
| ISSN: | 0022-3549 |
| Popis: | Ten 2-(4-arylthiosemicarbazidocarbonylthio)benzthiazoles were synthesized, characterized, and evaluated for their monoamine oxidase inhibitory and anticonvulsant activities. All substituted benzthiazoles inhibited activity of monoamine oxidase in rat brain homogenate where the degree of enzyme inhibition was higher with kynuramine as compared to tyramine and 5-hydroxytryptamine as the substrates. All substituted benzthiazoles possessed measurable anticonvulsant activity against pentylenetetrazol-induced convulsions. |
| Databáze: | OpenAIRE |
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