Serum apolipoprotein A-I, A-II and B levels and their discriminative values in relatives of patients with coronary artery disease
| Autor: | Hitoshi Kukita, Kunio Hiwada, Tatsuo Kokubu |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcohol Drinking Apolipoprotein B Coronary Disease Biology Coronary artery disease chemistry.chemical_compound Sex Factors High-density lipoprotein Internal medicine medicine Humans Triglycerides Serum cholesterol Apolipoproteins B Univariate analysis Apolipoprotein A-I Triglyceride Cholesterol Body Weight Cholesterol HDL Smoking nutritional and metabolic diseases Family aggregation Middle Aged medicine.disease Apolipoproteins Endocrinology chemistry biology.protein Female lipids (amino acids peptides and proteins) Lipoproteins HDL Cardiology and Cardiovascular Medicine Apolipoprotein A-II |
| Zdroj: | Atherosclerosis. 51:261-267 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/0021-9150(84)90173-4 |
| Popis: | Serum cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-C) and apolipoprotein (apo) A-I, A-II and B concentrations were measured in 109 first-degree relatives of patients with angiographically defined coronary artery disease (CAD). Age- and sex-matched healthy factory employees were chosen as a control group. Male relatives of the CAD patients had significantly higher serum triglyceride and apoB levels, and significantly lower serum HDL-C and apoA-I levels than the controls. Female relatives of the CAD patients also showed similar differences in serum HDL-C, apoA-I and apoB levels. Discriminant analysis indicated that apolipoproteins were better discriminators than lipids in both patients with CAD and their relatives. In univariate analysis, the best discriminator was apoB between male relatives and the controls, and apoA-I between female relatives and the controls. The percentage of exact classification achieved using three variables (serum cholesterol, triglyceride and HDL-C) was 74% in male relatives and 70% in female relatives. By adding variables of apoA-I and apoB, the percentage of correctly classified subjects was increased to 82% and 80%, respectively. These results indicate that serum apolipoprotein abnormalities are prevalent in relatives of the CAD patients. These abnormalities may explain the familial aggregation of CAD. |
| Databáze: | OpenAIRE |
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